Persulfidation is the Mechanism Underlying Sulfide-signaling of Autophagy

Overview

Journal Autophagy

Specialty Cell Biology

Date 2021 Jun 7

PMID 34097571

Citations 7

Authors

Cecilia Gotor

Angeles Aroca

Luis C Romero

Affiliations

Soon will be listed here.

Abstract

In this commentary, we highlight the findings described in a recent paper regarding the mechanism of HS regulation of macroautophagy/autophagy in mammalian cells and discuss the similarities/divergencies with plant cells. The main outcome is that the posttranslational modification of thiol groups of cysteine residues to form persulfides is a conserved molecular mechanism.

Citing Articles

Analysis of sulfide signaling in rice highlights specific drought responses.

Zhang J, Aroca A, Hervas M, Navarro J, Moreno I, Xie Y J Exp Bot. 2024; 75(16):5130-5145.

PMID: 38808567 PMC: 11349868. DOI: 10.1093/jxb/erae249.

The therapeutic potential for targeting CSE/HS signaling in macrophages against Escherichia coli infection.

Fu S, Wang Z, Han X, Xu Y, Miao J Vet Res. 2023; 54(1):71.

PMID: 37644526 PMC: 10466716. DOI: 10.1186/s13567-023-01203-8.

Sulfide promotes tolerance to drought through protein persulfidation in Arabidopsis.

Jurado-Flores A, Aroca A, Romero L, Gotor C J Exp Bot. 2023; 74(15):4654-4669.

PMID: 37148339 PMC: 10433926. DOI: 10.1093/jxb/erad165.

Proteome Dynamics of Persulfidation in Leaf Tissue under Light/Dark Conditions and Carbon Deprivation.

Jurado-Flores A, Gotor C, Romero L Antioxidants (Basel). 2023; 12(4).

PMID: 37107163 PMC: 10135009. DOI: 10.3390/antiox12040789.

Autophagy and multivesicular body pathways cooperate to protect sulfur assimilation and chloroplast functions.

Fu Y, Fan B, Li X, Bao H, Zhu C, Chen Z Plant Physiol. 2023; 192(2):886-909.

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