Comprehensive Echocardiographic Evaluation of the Right Heart in Patients with Pulmonary Vascular Diseases: the PVDOMICS Experience

Overview

Journal Eur Heart J Cardiovasc Imaging

Publisher Oxford University Press

Specialties Cardiology & Vascular Diseases
Radiology

Date 2021 Jun 7

PMID 34097027

Citations 9

Authors

Christine L Jellis

Margaret M Park

Aiden Abidov

Barry A Borlaug

Evan L Brittain

Robert Frantz

Paul M Hassoun

Evelyn M Horn

Wael A Jaber

Kim Jiwon

Maria G Karas

Deborah Kwon

Jane A Leopold

Bradley Maron

Stephen C Mathai

Reena Mehra

Franz Rischard

Erika B Rosenzweig

W H Wilson Tang

Rebecca Vanderpool

James D Thomas

Affiliations

Soon will be listed here.

Abstract

Aims: There is a wide spectrum of diseases associated with pulmonary hypertension, pulmonary vascular remodelling, and right ventricular dysfunction. The NIH-sponsored PVDOMICS network seeks to perform comprehensive clinical phenotyping and endophenotyping across these disorders to further evaluate and define pulmonary vascular disease.

Methods And Results: Echocardiography represents the primary non-invasive method to phenotype cardiac anatomy, function, and haemodynamics in these complex patients. However, comprehensive right heart evaluation requires the use of multiple echocardiographic parameters and optimized techniques to ensure optimal image acquisition. The PVDOMICS echo protocol outlines the best practice approach to echo phenotypic assessment of the right heart/pulmonary artery unit.

Conclusion: Novel workflow processes, methods for quality control, data for feasibility of measurements, and reproducibility of right heart parameters derived from this study provide a benchmark frame of reference. Lessons learned from this protocol will serve as a best practice guide for echocardiographic image acquisition and analysis across the spectrum of right heart/pulmonary vascular disease.

Citing Articles

Defining Echocardiographic Degrees of Right Heart Size and Function in Pulmonary Vascular Disease from the PVDOMICS Study.

Mukherjee M, Mathai S, Jellis C, Freed B, Yanek L, Agoglia H Circ Cardiovasc Imaging. 2024; 17(10).

PMID: 39691460 PMC: 11649025. DOI: 10.1161/circimaging.124.017074.

Association of Male Sex With Worse Right Ventricular Function and Survival in Pulmonary Hypertension in the Redefining Pulmonary Hypertension Through Pulmonary Vascular Disease Phenomics Cohort.

Shelburne N, Nian H, Beck G, Casanova N, Desai A, DuBrock H CHEST Pulm. 2024; 2(3).

PMID: 39524046 PMC: 11548889. DOI: 10.1016/j.chpulm.2024.100046.

Non-invasive prediction of pulmonary vascular disease-related exercise intolerance and survival in non-group 1 pulmonary hypertension.

Reddy Y, Dubrock H, Hassoun P, Hemnes A, Horn E, Leopold J Eur J Heart Fail. 2024; 26(11):2323-2336.

PMID: 39058211 PMC: 11760157. DOI: 10.1002/ejhf.3396.

Pulmonary hypertension across the spectrum of left heart and lung disease.

Borlaug B, Larive B, Frantz R, Hassoun P, Hemnes A, Horn E Eur J Heart Fail. 2024; 26(7):1642-1651.

PMID: 38837273 PMC: 11269034. DOI: 10.1002/ejhf.3302.

Relationship of TAPSE Normalized by Right Ventricular Area With Pulmonary Compliance, Exercise Capacity, and Clinical Outcomes.

Tao R, Dharmavaram N, El Shaer A, Heffernan S, Tu W, Ma J Circ Heart Fail. 2024; 17(5):e010826.

PMID: 38708598 PMC: 11108738. DOI: 10.1161/CIRCHEARTFAILURE.123.010826.

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