Enhancing the ROS Generation Ability of a Rhodamine-decorated Iridium(iii) Complex by Ligand Regulation for Endoplasmic Reticulum-targeted Photodynamic Therapy

Overview

Journal Chem Sci

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2021 Jun 7

PMID 34094433

Citations 12

Authors

Lihua Zhou

Fangfang Wei

Jingjing Xiang

Hongfeng Li

Chunbin Li

Pengfei Zhang

Chuangjun Liu

Ping Gong

Lintao Cai

Keith Man-Chung Wong

Affiliations

Soon will be listed here.

Abstract

The endoplasmic reticulum (ER) is a very important organelle responsible for crucial biosynthetic, sensing, and signalling functions in eukaryotic cells. In this work, we established a strategy of ligand regulation to enhance the singlet oxygen generation capacity and subcellular organelle localization ability of a rhodamine-decorated iridium(iii) complex by variation of the cyclometallating ligand. The resulting metal complex showed outstanding reactive oxygen species generation efficiency (1.6-fold higher than that of rose bengal in CHCN) and highly specific ER localization ability, which demonstrated the promise of the metal-based photo-theranostic agent by simultaneously tuning the photochemical/physical and biological properties. Additionally, low dark cytotoxicity, high photostability and selective tumour cell uptake were featured by this complex to demonstrate it as a promising candidate in photodynamic therapy (PDT) applications. near infrared fluorescence (NIRF) imaging and tumour PDT were investigated and showed preferential accumulation at the tumour site and remarkable tumour growth suppression, respectively.

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