Is There Any Relationship Between Autism and Pineal Gland Volume?

Overview

Journal Pol J Radiol

Publisher Termedia

Specialty Radiology

Date 2021 Jun 7

PMID 34093919

Authors

Feride F Gorgulu

Ayse S Koc

Affiliations

Soon will be listed here.

Abstract

Purpose: Abnormalities in melatonin physiology and circadian rhythm are detected in patients with autism. Melatonin is produced predominantly in the pineal gland and the amount of melatonin released is proportional to the pineal gland volume. This study aimed to examine whether the pineal gland volume in children with autism is different from that in healthy children.

Material And Methods: Brain magnetic resonance images (MRI) of 120 paediatric patients with autism and 82 control paediatric subjects were examined; pineal parenchymal volume (PPV), pineal cyst rate (PCR), and total pineal gland volume (TPGV) were measured using a multimodality viewer (MMV), but only the TPGVs were measured using a tumour tracking (TT) method. Measurements were taken by 2 separate radiologists.

Results: In patients with autism, the PPV and TPGV according to MMV, and the TPGV according to TT were significantly lower, and the PCR was significantly higher. Moreover, the ratio of PPV to TPGV was significantly lower in the autism patient group. In both groups, the TPGVs were significantly lower in the autism patient group than the controls among all age groups.

Conclusions: Our study was the first to examine TPGVs in detail in paediatric patients with autism using 2 different methods. Low PPV-TPGV and high PCR have been observed in autism. This study also provides comparable reference values for pineal gland size in healthy children or autistic children aged 2-17 years. These results show promising potential for further research to understand the relationship between autism pathogenesis and the pineal gland.

References

Kunz D, Schmitz S, Mahlberg R, Mohr A, Stoter C, Wolf K . A new concept for melatonin deficit: on pineal calcification and melatonin excretion. Neuropsychopharmacology. 2000; 21(6):765-72. DOI: 10.1016/S0893-133X(99)00069-X. View

Emet M, Ozcan H, Ozel L, Yayla M, Halici Z, Hacimuftuoglu A . A Review of Melatonin, Its Receptors and Drugs. Eurasian J Med. 2016; 48(2):135-41. PMC: 4970552. DOI: 10.5152/eurasianjmed.2015.0267. View

Jenabi E, Ataei S, Bashirian S . Evaluation of drug interventions for the treatment of sleep disorders in children with autism spectrum disorders: a systematic review. Korean J Pediatr. 2019; 62(11):405-409. PMC: 6881205. DOI: 10.3345/kjp.2019.00668. View

Cohen S, Conduit R, Lockley S, Rajaratnam S, Cornish K . The relationship between sleep and behavior in autism spectrum disorder (ASD): a review. J Neurodev Disord. 2014; 6(1):44. PMC: 4271434. DOI: 10.1186/1866-1955-6-44. View

Ross A, Hazlett H, Garrett N, Wilkerson C, Piven J . Moderate sedation for MRI in young children with autism. Pediatr Radiol. 2005; 35(9):867-71. DOI: 10.1007/s00247-005-1499-2. View

Malow B, Findling R, Schroder C, Maras A, Breddy J, Nir T . Sleep, Growth, and Puberty After 2 Years of Prolonged-Release Melatonin in Children With Autism Spectrum Disorder. J Am Acad Child Adolesc Psychiatry. 2020; 60(2):252-261.e3. PMC: 8084705. DOI: 10.1016/j.jaac.2019.12.007. View

Tan D, Xu B, Zhou X, Reiter R . Pineal Calcification, Melatonin Production, Aging, Associated Health Consequences and Rejuvenation of the Pineal Gland. Molecules. 2018; 23(2). PMC: 6017004. DOI: 10.3390/molecules23020301. View

Patel S, Rahmani B, Gandhi J, Seyam O, Joshi G, Reid I . Revisiting the pineal gland: a review of calcification, masses, precocious puberty, and melatonin functions. Int J Neurosci. 2019; 130(5):464-475. DOI: 10.1080/00207454.2019.1692838. View

Mayo J, Sainz R, Tan D, Antolin I, Rodriguez C, Reiter R . Melatonin and Parkinson's disease. Endocrine. 2005; 27(2):169-78. DOI: 10.1385/ENDO:27:2:169. View

10.

Hasegawa A, Ohtsubo K, Mori W . Pineal gland in old age; quantitative and qualitative morphological study of 168 human autopsy cases. Brain Res. 1987; 409(2):343-9. DOI: 10.1016/0006-8993(87)90720-7. View

11.

Cuomo B, Vaz S, Lee E, Thompson C, Rogerson J, Falkmer T . Effectiveness of Sleep-Based Interventions for Children with Autism Spectrum Disorder: A Meta-Synthesis. Pharmacotherapy. 2017; 37(5):555-578. DOI: 10.1002/phar.1920. View

12.

Pfeffer M, Korf H, Wicht H . Synchronizing effects of melatonin on diurnal and circadian rhythms. Gen Comp Endocrinol. 2017; 258:215-221. DOI: 10.1016/j.ygcen.2017.05.013. View

13.

Schmid H, Requintina P, Oxenkrug G, Sturner W . Calcium, calcification, and melatonin biosynthesis in the human pineal gland: a postmortem study into age-related factors. J Pineal Res. 1994; 16(4):178-83. DOI: 10.1111/j.1600-079x.1994.tb00098.x. View

14.

El-Ansary A, Hassan W, Daghestani M, Al-Ayadhi L, Ben Bacha A . Preliminary evaluation of a novel nine-biomarker profile for the prediction of autism spectrum disorder. PLoS One. 2020; 15(1):e0227626. PMC: 6964874. DOI: 10.1371/journal.pone.0227626. View

15.

Nichols D . N,N-dimethyltryptamine and the pineal gland: Separating fact from myth. J Psychopharmacol. 2017; 32(1):30-36. DOI: 10.1177/0269881117736919. View

16.

Sumida M, Barkovich A, Newton T . Development of the pineal gland: measurement with MR. AJNR Am J Neuroradiol. 1996; 17(2):233-6. PMC: 8338352. View

17.

Pu Y, Mahankali S, Hou J, Li J, Lancaster J, Gao J . High prevalence of pineal cysts in healthy adults demonstrated by high-resolution, noncontrast brain MR imaging. AJNR Am J Neuroradiol. 2007; 28(9):1706-9. PMC: 8134222. DOI: 10.3174/ajnr.A0656. View

18.

Whitehead M, Oh C, Choudhri A . Incidental pineal cysts in children who undergo 3-T MRI. Pediatr Radiol. 2013; 43(12):1577-83. DOI: 10.1007/s00247-013-2742-x. View

19.

Daghighi M, Rezaei V, Zarrintan S, Pourfathi H . Intracranial physiological calcifications in adults on computed tomography in Tabriz, Iran. Folia Morphol (Warsz). 2007; 66(2):115-9. View

20.

Maruani A, Dumas G, Beggiato A, Traut N, Peyre H, Cohen-Freoua A . Morning Plasma Melatonin Differences in Autism: Beyond the Impact of Pineal Gland Volume. Front Psychiatry. 2019; 10:11. PMC: 6372551. DOI: 10.3389/fpsyt.2019.00011. View