Development of a Patient-Centered Software System to Facilitate Effective Management of Bipolar Disorder

Overview

Journal Psychopharmacol Bull

Specialty Pharmacology

Date 2021 Jun 7

PMID 34092819

Citations 2

Authors

Charles L Bowden

Richard Priesmeyer

Mauricio Tohen

Vivek Singh

Joseph R Calabrese

Terry Ketter

Andrew Nierenberg

Michael E Thase

Gregg Siegel

Leslie H Siegel

Jim Mintz

Rif S El-Mallakh

Susan L McElroy

Melissa Martinez

Affiliations

Soon will be listed here.

Abstract

Objective: Self-management of bipolar disorder (BD) is an important component of treatment.

Methods: We developed a patient-centered computational software system based on concepts from nonlinear systems (chaos) theory with mobile access to assist in managing BD known as KIOS. KIOS tracks interacting symptoms to determine theprecise state of a BD patient. Once the patient's state is identified and the trajectory of the patient established, specific advice is generated to help manage the course of the disease. KIOS also provides analytics that can be used by clinicians and researchers to track outcomes and the course of illness. A 12-week field test was completed.

Results: In 20 BD subjects, use of KIOS was associated with improvements in primary symptom categories of BD. Usability and generated advice were rated as a median of 6 out of a maximum of 7.

Conclusions: The KIOS focus on change illuminates problems in the same way that humans experience them, implying that the future state will be consequent to changes made to impact the current state. Randomized clinical trial is indicated.

Citing Articles

The use of a smartphone app for self-monitoring by patients with bipolar disorder being treated in a primary care setting.

Elsayed O, Cecil J, Priesmeyer R, Siegel G, Siegel P, El-Mallakh R J Family Med Prim Care. 2025; 14(1):85-89.

PMID: 39989584 PMC: 11845010. DOI: 10.4103/jfmpc.jfmpc_483_24.

Barriers and Facilitators of User Engagement With Digital Mental Health Interventions for People With Psychosis or Bipolar Disorder: Systematic Review and Best-Fit Framework Synthesis.

Eisner E, Faulkner S, Allan S, Ball H, Di Basilio D, Nicholas J JMIR Ment Health. 2025; 12:e65246.

PMID: 39832352 PMC: 11791459. DOI: 10.2196/65246.

Development and Evaluation of a Digital App for Patient Self-Management of Opioid Use Disorder: Usability, Acceptability, and Utility Study.

King Jr V, Siegel G, Priesmeyer H, Siegel L, Potter J JMIR Form Res. 2024; 8:e48068.

PMID: 38557501 PMC: 11019416. DOI: 10.2196/48068.

KIOS: A smartphone app for self-monitoring for patients with bipolar disorder.

Pahwa M, McElroy S, Priesmeyer R, Siegel G, Siegel P, Nuss S Bipolar Disord. 2023; 26(1):84-92.

PMID: 37340215 PMC: 10730767. DOI: 10.1111/bdi.13362.

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