Clinical Frailty Score As an Independent Predictor of Outcome in COVID-19 Hospitalised Patients

Overview

Journal Eur Geriatr Med

Specialty Geriatrics

Date 2021 Jun 4

PMID 34086193

Citations 10

Authors

Gouri Koduri

Sriya Gokaraju

Maria Darda

Vinod Warrier

Irina Duta

Fiona Hayes

Iman El Sayed

Yasser Noeman-Ahmed

Affiliations

Soon will be listed here.

Abstract

Purpose Of The Study: We explored potential predictive variables associated with outcomes using baseline clinical parameters of 500 hospitalised patients with COVID -19 in a single centre, UK.

Methods: Retrospective study collecting demographic and clinical characteristics of patients admitted at Southend University Hospital from 20th February to 7th May 2020.

Results: The mean age of the cohort admitted to hospital with Covid-19 was 69.4 and 58% were over 70. Comorbidities were more frequently observed in non-survivors, whose mean Clinical Frailty Scale was significantly higher (5 vs 3) than survivors, p < 0.001. In addition, mean C-reactive protein was significantly higher.

Conclusion: Older and frailer patients with high inflammatory markers were at risk of poor outcomes. Integrated frailty and age-based risk stratification is essential, in addition to monitoring saturation /FiO2 ratio (SFR) and inflammatory markers throughout the disease course to allow for early intervention to improve patient outcomes. A frailty-based risk-stratification approach, rather than age may prove more valuable when considering interventions in patients with multiple comorbidities.

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