Genetics of Ocular NAD+-dependent Alcohol Dehydrogenase and Aldehyde Dehydrogenase in the Mouse: Evidence for Genetic Identity with Stomach Isozymes and Localization of Ahd-4 on Chromosome 11 Near Trembler

Overview

Journal Biochem Genet

Specialty Molecular Biology

Date 1988 Apr 1

PMID 3408474

Citations 6

Authors

R S Holmes

R A Popp

J L Vandeberg

Affiliations

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Abstract

Electrophoretic and activity variation of the stomach and ocular isozyme of aldehyde dehydrogenase (designated AHD-4) was observed between C57BL/6J and SWR/J inbred strains of mice. The phenotypes were inherited in a normal mendelian fashion, with two alleles at a single locus (Ahd-4) showing codominant expression. The alleles assorted independently of those at Adh-3 [encoding the stomach and ocular isozyme of alcohol dehydrogenase (ADH-C2)] on chromosome 3. Three chromosome 11 markers, hemoglobin alpha-chain (Hba), trembler (Tr), and rex (Re), were used in backcross analyses which established that Ahd-4 is closely linked to trembler. The distribution patterns for stomach and ocular AHD-4 phenotypes were examined among SWXL recombinant inbred mice, and those for stomach and ocular ADH-C2 among BXD recombinant inbred strains. The data provided evidence for the genetic identity of stomach and ocular ADH-C2 and of stomach and ocular AHD-4.

Citing Articles

Aldehyde dehydrogenase (ALDH) isozymes in the gray short-tailed opossum (Monodelphis domestica): tissue and subcellular distribution and biochemical genetics of ALDH3.

Holmes R, van Oorschot R, Vandeberg J Biochem Genet. 1991; 29(3-4):163-75.

PMID: 1859355

Comparative map for mice and humans.

Nadeau J, Davisson M, Doolittle D, Grant P, Hillyard A, Kosowsky M Mamm Genome. 1991; 1 Spec No:S461-515.

PMID: 1799811 DOI: 10.1007/BF00656504.

Mouse map of paralogous genes.

Nadeau J, Kosowsky M Mamm Genome. 1991; 1 Spec No:S433-60.

PMID: 1799810 DOI: 10.1007/BF00656503.

Mouse chromosome 11.

Buchberg A, Moskow J, Buckwalter M, Camper S Mamm Genome. 1991; 1 Spec No:S158-91.

PMID: 1799798 DOI: 10.1007/BF00656492.

Mouse chromosome 11.

Buchberg A, Buckwalter M, Camper S Mamm Genome. 1992; 3 Spec No:S162-81.

PMID: 1498430 DOI: 10.1007/BF00648429.

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