Role of Pyroptosis in Diabetes and Its Therapeutic Implications

Overview

Journal J Inflamm Res

Publisher Dove Medical Press

Date 2021 Jun 3

PMID 34079327

Citations 30

Authors

Abdullah Al Mamun

Yanqing Wu

Fatema Nasrin

Afroza Akter

Masuma Afrin Taniya

Fahad Munir

Chang Jia

Jian Xiao

Affiliations

Soon will be listed here.

Abstract

Pyroptosis is mainly considered as a new pro-inflammatory mediated-programmed cell death. In addition, pyroptosis is described by gasdermin-induced pore formation on the membrane, cell swelling and rapid lysis, and several pro-inflammatory mediators interleukin-1β (IL-1β) and interleukin-18 (IL-18) release. Extensive studies have shown that pyroptosis is commonly involved by activating the caspase-1-dependent canonical pathway and caspase-4/5/11-dependent non-canonical pathway. However, pyroptosis facilitates local inflammation and inflammatory responses. Current researches have reported that pyroptosis promotes the progression of several diabetic complications. Emerging studies have suggested that some potential molecules targeting the pyroptosis and inflammasome signaling pathways could be a novel therapeutic avenue for managing and treating diabetes and its complications in the near future. Our narrative review concisely describes the possible mechanism of pyroptosis and its progressive understanding of the development of diabetic complications.

Citing Articles

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Xie R, Gao H, Xie H, Xie C, Li T BMC Cardiovasc Disord. 2025; 25(1):176.

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Estimation of noncanonical pyroptosis biomarkers gasdermin D and caspase 4 in gingiva of periodontitis and diabetes patients: An observational cross-sectional study.

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Cheng C, Yi M, Wang L, Huang Y Front Immunol. 2024; 15:1456244.

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