Marine Natural Products from Tunicates and Their Associated Microbes

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2021 Jun 2

PMID 34073515

Citations 20

Authors

Chatragadda Ramesh

Bhushan Rao Tulasi

Mohanraju Raju

Narsinh Thakur

Laurent Dufosse

Affiliations

Soon will be listed here.

Abstract

Marine tunicates are identified as a potential source of marine natural products (MNPs), demonstrating a wide range of biological properties, like antimicrobial and anticancer activities. The symbiotic relationship between tunicates and specific microbial groups has revealed the acquisition of microbial compounds by tunicates for defensive purpose. For instance, yellow pigmented compounds, "tambjamines", produced by the tunicate, (Sluiter, 1909), primarily originated from their bacterial symbionts, which are involved in their chemical defense function, indicating the ecological role of symbiotic microbial association with tunicates. This review has garnered comprehensive literature on MNPs produced by tunicates and their symbiotic microbionts. Various sections covered in this review include tunicates' ecological functions, biological activities, such as antimicrobial, antitumor, and anticancer activities, metabolic origins, utilization of invasive tunicates, and research gaps. Apart from the literature content, 20 different chemical databases were explored to identify tunicates-derived MNPs. In addition, the management and exploitation of tunicate resources in the global oceans are detailed for their ecological and biotechnological implications.

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References

Watters D . Ascidian Toxins with Potential for Drug Development. Mar Drugs. 2018; 16(5). PMC: 5983293. DOI: 10.3390/md16050162. View

Xu Y, Kersten R, Nam S, Lu L, Al-Suwailem A, Zheng H . Bacterial biosynthesis and maturation of the didemnin anti-cancer agents. J Am Chem Soc. 2012; 134(20):8625-32. PMC: 3401512. DOI: 10.1021/ja301735a. View

Nguyen M, Imanishi M, Kurogi T, Wan X, Ishmael J, McPhail K . Synthetic Access to the Mandelalide Family of Macrolides: Development of an Anion Relay Chemistry Strategy. J Org Chem. 2018; 83(8):4287-4306. PMC: 5910188. DOI: 10.1021/acs.joc.8b00268. View

Franks A, Egan S, Holmstrom C, James S, Lappin-Scott H, Kjelleberg S . Inhibition of fungal colonization by Pseudoalteromonas tunicata provides a competitive advantage during surface colonization. Appl Environ Microbiol. 2006; 72(9):6079-87. PMC: 1563610. DOI: 10.1128/AEM.00559-06. View

Urdiales J, Morata P, Nunez de Castro I, Sanchez-Jimenez F . Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates. Cancer Lett. 1996; 102(1-2):31-7. DOI: 10.1016/0304-3835(96)04151-1. View

Chen L, Hu J, Xu J, Shao C, Wang G . Biological and Chemical Diversity of Ascidian-Associated Microorganisms. Mar Drugs. 2018; 16(10). PMC: 6212887. DOI: 10.3390/md16100362. View

Aiello A, Carbonelli S, Fattorusso E, Iuvone T, Menna M . New bioactive sulfated metabolites from the Mediterranean tunicate Sidnyum turbinatum. J Nat Prod. 2001; 64(2):219-21. DOI: 10.1021/np000438c. View

Azumi K, Yokosawa H, Ishii S . Halocyamines: novel antimicrobial tetrapeptide-like substances isolated from the hemocytes of the solitary ascidian Halocynthia roretzi. Biochemistry. 1990; 29(1):159-65. DOI: 10.1021/bi00453a021. View

Gonzalez-Santiago L, Suarez Y, Zarich N, Munoz-Alonso M, Cuadrado A, Martinez T . Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation. Cell Death Differ. 2006; 13(11):1968-81. DOI: 10.1038/sj.cdd.4401898. View

10.

Rashid M, Gustafson K, Boyd M . New cytotoxic N-methylated beta-carboline alkaloids from the marine ascidian Eudistoma gilboverde. J Nat Prod. 2001; 64(11):1454-6. DOI: 10.1021/np010214+. View

11.

Franchi N, Ballarin L . Immunity in Protochordates: The Tunicate Perspective. Front Immunol. 2017; 8:674. PMC: 5465252. DOI: 10.3389/fimmu.2017.00674. View

12.

Costa Leal M, Sheridan C, Osinga R, Dionisio G, Miranda Rocha R, Silva B . Marine microorganism-invertebrate assemblages: perspectives to solve the "supply problem" in the initial steps of drug discovery. Mar Drugs. 2014; 12(7):3929-52. PMC: 4113807. DOI: 10.3390/md12073929. View

13.

WASSERMAN H, Friedland D, Morrison D . A novel dipyrrolyldipyrromethene prodigiosin analog from Serratia marcescens. Tetrahedron Lett. 1968; 6:641-4. DOI: 10.1016/s0040-4039(00)75602-4. View

14.

Atmaca H, Bozkurt E, Uzunoglu S, Uslu R, Karaca B . A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells. Toxicol Lett. 2013; 221(2):128-36. DOI: 10.1016/j.toxlet.2013.06.213. View

15.

Gouiffes D, Juge M, Grimaud N, Welin L, Sauviat M, Barbin Y . Bistramide A, a new toxin from the urochordata Lissoclinum bistratum Sluiter: isolation and preliminary characterization. Toxicon. 1988; 26(12):1129-36. DOI: 10.1016/0041-0101(88)90297-8. View

16.

Tapiolas D, Bowden B, Abou-Mansour E, Willis R, Doyle J, Muirhead A . Eusynstyelamides A, B, and C, nNOS inhibitors, from the ascidian Eusynstyela latericius. J Nat Prod. 2009; 72(6):1115-20. DOI: 10.1021/np900099j. View

17.

Dewapriya P, Khalil Z, Prasad P, Salim A, Cruz-Morales P, Marcellin E . Talaropeptides A-D: Structure and Biosynthesis of Extensively -methylated Linear Peptides From an Australian Marine Tunicate-Derived sp. Front Chem. 2018; 6:394. PMC: 6131563. DOI: 10.3389/fchem.2018.00394. View

18.

Choi H, Hwang H, Chin J, Kim E, Lee J, Nam S . Tuberatolides, potent FXR antagonists from the Korean marine tunicate Botryllus tuberatus. J Nat Prod. 2010; 74(1):90-4. DOI: 10.1021/np100489u. View

19.

Egan S, James S, Holmstrom C, Kjelleberg S . Correlation between pigmentation and antifouling compounds produced by Pseudoalteromonas tunicata. Environ Microbiol. 2002; 4(8):433-42. DOI: 10.1046/j.1462-2920.2002.00322.x. View

20.

Izbicka E, Lawrence R, Raymond E, Eckhardt G, Faircloth G, Jimeno J . In vitro antitumor activity of the novel marine agent, ecteinascidin-743 (ET-743, NSC-648766) against human tumors explanted from patients. Ann Oncol. 1998; 9(9):981-7. DOI: 10.1023/A:1008224322396. View