Zebrafish As a Model for the Study of Lipid-Lowering Drug-Induced Myopathies

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Jun 2

PMID 34073503

Citations 4

Authors

Magda Dubinska-Magiera

Marta Migocka-Patrzalek

Damian Lewandowski

Malgorzata Daczewska

Krzysztof Jagla

Affiliations

Soon will be listed here.

Abstract

Drug-induced myopathies are classified as acquired myopathies caused by exogenous factors. These pathological conditions develop in patients without muscle disease and are triggered by a variety of medicaments, including lipid-lowering drugs (LLDs) such as statins, fibrates, and ezetimibe. Here we summarise the current knowledge gained via studies conducted using various models, such as cell lines and mammalian models, and compare them with the results obtained in zebrafish () studies. Zebrafish have proven to be an excellent research tool for studying dyslipidaemias as a model of these pathological conditions. This system enables in-vivo characterization of drug and gene candidates to further the understanding of disease aetiology and develop new therapeutic strategies. Our review also considers important environmental issues arising from the indiscriminate use of LLDs worldwide. The widespread use and importance of drugs such as statins and fibrates justify the need for the meticulous study of their mechanism of action and the side effects they cause.

Citing Articles

Elucidating the Effects of the Lipids Regulators Fibrates and Statins on the Health Status of Finfish Species: A Review.

Blonc M, Lima J, Balasch J, Tort L, Gravato C, Teles M Animals (Basel). 2023; 13(5).

PMID: 36899648 PMC: 10000190. DOI: 10.3390/ani13050792.

Statins Induce Locomotion and Muscular Phenotypes in That Are Reminiscent of Human Myopathy: Evidence for the Role of the Chloride Channel Inhibition in the Muscular Phenotypes.

Al-Sabri M, Behare N, Alsehli A, Berkins S, Arora A, Antoniou E Cells. 2022; 11(22).

PMID: 36428957 PMC: 9688544. DOI: 10.3390/cells11223528.

Assessment of the Preventive Effect of L-carnitine on Post-statin Muscle Damage in a Zebrafish Model.

Niedbalska-Tarnowska J, Ochenkowska K, Migocka-Patrzalek M, Dubinska-Magiera M Cells. 2022; 11(8).

PMID: 35455976 PMC: 9032104. DOI: 10.3390/cells11081297.

In vivo toxicity of bioreactor-grown biomass and exopolysaccharides from Malaysian tiger milk mushroom mycelium for potential future health applications.

Ahmad Usuldin S, Wan-Mohtar W, Ilham Z, Jamaludin A, Abdullah N, Rowan N Sci Rep. 2021; 11(1):23079.

PMID: 34845290 PMC: 8629991. DOI: 10.1038/s41598-021-02486-7.

References

Sztal T, Ruparelia A, Williams C, Bryson-Richardson R . Using Touch-evoked Response and Locomotion Assays to Assess Muscle Performance and Function in Zebrafish. J Vis Exp. 2016; (116). PMC: 5226210. DOI: 10.3791/54431. View

Venturi E, Lindsay C, Lotteau S, Yang Z, Steer E, Witschas K . Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform. Br J Pharmacol. 2017; 175(6):938-952. PMC: 5825303. DOI: 10.1111/bph.14136. View

Irwin J, Fenning A, Vella R . Geranylgeraniol prevents statin-induced skeletal muscle fatigue without causing adverse effects in cardiac or vascular smooth muscle performance. Transl Res. 2019; 215:17-30. DOI: 10.1016/j.trsl.2019.08.004. View

Evangelisti C, Paganelli F, Giuntini G, Mattioli E, Cappellini A, Ramazzotti G . Lamin A and Prelamin A Counteract Migration of Osteosarcoma Cells. Cells. 2020; 9(3). PMC: 7140691. DOI: 10.3390/cells9030774. View

DAmico L, Scott I, Jungblut B, Stainier D . A mutation in zebrafish hmgcr1b reveals a role for isoprenoids in vertebrate heart-tube formation. Curr Biol. 2007; 17(3):252-9. DOI: 10.1016/j.cub.2006.12.023. View

Ge Y, Lu X, Peng Q, Shu X, Wang G . Clinical Characteristics of Anti-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Antibodies in Chinese Patients with Idiopathic Inflammatory Myopathies. PLoS One. 2015; 10(10):e0141616. PMC: 4624805. DOI: 10.1371/journal.pone.0141616. View

Mahdavi Gorabi A, Kiaie N, Hajighasemi S, Banach M, Penson P, Jamialahmadi T . Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications. J Clin Med. 2019; 8(12). PMC: 6947613. DOI: 10.3390/jcm8122051. View

Madden L, Juhas M, Kraus W, Truskey G, Bursac N . Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs. Elife. 2015; 4:e04885. PMC: 4337710. DOI: 10.7554/eLife.04885. View

Whitehead N, Kim M, Bible K, Adams M, Froehner S . A new therapeutic effect of simvastatin revealed by functional improvement in muscular dystrophy. Proc Natl Acad Sci U S A. 2015; 112(41):12864-9. PMC: 4611601. DOI: 10.1073/pnas.1509536112. View

10.

Miller D, Spence J . Clinical pharmacokinetics of fibric acid derivatives (fibrates). Clin Pharmacokinet. 1998; 34(2):155-62. DOI: 10.2165/00003088-199834020-00003. View

11.

Gomes M, Lecker S, Jagoe R, Navon A, GOLDBERG A . Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Proc Natl Acad Sci U S A. 2001; 98(25):14440-5. PMC: 64700. DOI: 10.1073/pnas.251541198. View

12.

Wang M, Casey P . Protein prenylation: unique fats make their mark on biology. Nat Rev Mol Cell Biol. 2016; 17(2):110-22. DOI: 10.1038/nrm.2015.11. View

13.

Verdoodt A, Honore P, Jacobs R, De Waele E, Van Gorp V, De Regt J . Do Statins Induce or Protect from Acute Kidney Injury and Chronic Kidney Disease: An Update Review in 2018. J Transl Int Med. 2018; 6(1):21-25. PMC: 5874483. DOI: 10.2478/jtim-2018-0005. View

14.

Coimbra A, Peixoto M, Coelho I, Lacerda R, Carvalho A, Gesto M . Chronic effects of clofibric acid in zebrafish (Danio rerio): a multigenerational study. Aquat Toxicol. 2015; 160:76-86. DOI: 10.1016/j.aquatox.2015.01.013. View

15.

Vaklavas C, Chatzizisis Y, Ziakas A, Zamboulis C, Giannoglou G . Molecular basis of statin-associated myopathy. Atherosclerosis. 2008; 202(1):18-28. DOI: 10.1016/j.atherosclerosis.2008.05.021. View

16.

Cassar S, Adatto I, Freeman J, Gamse J, Iturria I, Lawrence C . Use of Zebrafish in Drug Discovery Toxicology. Chem Res Toxicol. 2019; 33(1):95-118. PMC: 7162671. DOI: 10.1021/acs.chemrestox.9b00335. View

17.

Thorpe J, Doitsidou M, Ho S, Raz E, Farber S . Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. Dev Cell. 2004; 6(2):295-302. DOI: 10.1016/s1534-5807(04)00032-2. View

18.

Xie X, Liu J, Hu B, Xiao W . Zebrafish foxo3b negatively regulates canonical Wnt signaling to affect early embryogenesis. PLoS One. 2011; 6(9):e24469. PMC: 3168510. DOI: 10.1371/journal.pone.0024469. View

19.

Kawata R, Yokoi T . Analysis of a Skeletal Muscle Injury and Drug Interactions in Lovastatin- and Fenofibrate-Coadministered Dogs. Int J Toxicol. 2019; 38(3):192-201. DOI: 10.1177/1091581819844793. View

20.

Ernster L, Dallner G . Biochemical, physiological and medical aspects of ubiquinone function. Biochim Biophys Acta. 1995; 1271(1):195-204. DOI: 10.1016/0925-4439(95)00028-3. View