Cord-Blood-Derived Professional Antigen-Presenting Cells: Functions and Applications in Current and Prospective Cell Therapies

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Jun 2

PMID 34072923

Citations 3

Authors

Sarah Cunningham

Holger Hackstein

Affiliations

Soon will be listed here.

Abstract

Human umbilical cord blood (UCB) represents a valuable source of hematopoietic stem cells, particularly for patients lacking a matching donor. UCB provides practical advantages, including a lower risk of graft-versus-host-disease and permissive human leukocyte antigen mismatching. These advantageous properties have so far been applied for stem cell, mesenchymal stromal cell, and chimeric antigen receptor T cell therapies. However, UCB-derived professional antigen-presenting cells are increasingly being utilized in the context of immune tolerance and regenerative therapy. Here, we review the cell-specific characteristics as well as recent advancements in UCB-based cell therapies focusing on dendritic cells, monocytes, B lymphocytes, innate lymphoid cells, and macrophages.

Citing Articles

Functional Heterogeneity of Umbilical Cord Blood Monocyte-Derived Dendritic Cells.

Schweiger P, Hamann L, Strobel J, Weisbach V, Wandersee A, Christ J J Immunol. 2024; 213(2):115-124.

PMID: 38809115 PMC: 11215632. DOI: 10.4049/jimmunol.2400036.

Immune profiling reveals umbilical cord blood mononuclear cells from South India display an IL-8 dominant, CXCL-10 deficient polyfunctional monocyte response to pathogen-associated molecular patterns that is distinct from adult blood cells.

Adiga V, Bindhu H, Ahmed A, Chetan Kumar N, Tripathi H, DSouza G Clin Exp Immunol. 2024; 217(3):263-278.

PMID: 38695079 PMC: 11310697. DOI: 10.1093/cei/uxae034.

Umbilical Cord Blood-Derived Monocytes as A Reliable Source of Functional Macrophages for Biomedical Research.

Torabi S, Zarrabi M, Hossein-Khannazer N, Lotfinia M, Nouri M, Gramignoli R Cell J. 2023; 25(8):524-535.

PMID: 37641414 PMC: 10542205. DOI: 10.22074/cellj.2023.1990203.1238.

References

Niederwieser D, Herold M, Woloszczuk W, Aulitzky W, Meister B, Tilg H . Endogenous IFN-gamma during human bone marrow transplantation. Analysis of serum levels of interferon and interferon-dependent secondary messages. Transplantation. 1990; 50(4):620-5. DOI: 10.1097/00007890-199010000-00019. View

Ruggeri A, Paviglianiti A, Gluckman E, Rocha V . Impact of HLA in cord blood transplantation outcomes. HLA. 2016; 87(6):413-21. DOI: 10.1111/tan.12792. View

Erices A, Conget P, Minguell J . Mesenchymal progenitor cells in human umbilical cord blood. Br J Haematol. 2000; 109(1):235-42. DOI: 10.1046/j.1365-2141.2000.01986.x. View

Cui X, Chopp M, Shehadah A, Zacharek A, Kuzmin-Nichols N, Sanberg C . Therapeutic benefit of treatment of stroke with simvastatin and human umbilical cord blood cells: neurogenesis, synaptic plasticity, and axon growth. Cell Transplant. 2012; 21(5):845-56. PMC: 3442771. DOI: 10.3727/096368911X627417. View

Adkins B, Leclerc C, Marshall-Clarke S . Neonatal adaptive immunity comes of age. Nat Rev Immunol. 2004; 4(7):553-64. DOI: 10.1038/nri1394. View

Naderi N, Moazzeni S, Pourfathollah A, Alimoghaddam K . High expression of Fas ligand on cord blood dendritic cells: a possible immunoregulatory mechanism after cord blood transplantation. Transplant Proc. 2011; 43(10):3913-9. DOI: 10.1016/j.transproceed.2011.10.040. View

Kollmann T, Crabtree J, Rein-Weston A, Blimkie D, Thommai F, Wang X . Neonatal innate TLR-mediated responses are distinct from those of adults. J Immunol. 2009; 183(11):7150-60. PMC: 4556237. DOI: 10.4049/jimmunol.0901481. View

De Wit D, Tonon S, Olislagers V, Goriely S, Boutriaux M, Goldman M . Impaired responses to toll-like receptor 4 and toll-like receptor 3 ligands in human cord blood. J Autoimmun. 2003; 21(3):277-81. DOI: 10.1016/j.jaut.2003.08.003. View

Poltavets A, Vishnyakova P, Elchaninov A, Sukhikh G, Fatkhudinov T . Macrophage Modification Strategies for Efficient Cell Therapy. Cells. 2020; 9(6). PMC: 7348902. DOI: 10.3390/cells9061535. View

10.

Griffin D, Rothstein T . Human b1 cell frequency: isolation and analysis of human b1 cells. Front Immunol. 2012; 3:122. PMC: 3360193. DOI: 10.3389/fimmu.2012.00122. View

11.

Corliss B, Azimi M, Munson J, Peirce S, Murfee W . Macrophages: An Inflammatory Link Between Angiogenesis and Lymphangiogenesis. Microcirculation. 2015; 23(2):95-121. PMC: 4744134. DOI: 10.1111/micc.12259. View

12.

Salio M, Dulphy N, Renneson J, Herbert M, McMichael A, Marchant A . Efficient priming of antigen-specific cytotoxic T lymphocytes by human cord blood dendritic cells. Int Immunol. 2003; 15(10):1265-73. DOI: 10.1093/intimm/dxg123. View

13.

Robbins J, Zeldovich V, Poukchanski A, Boothroyd J, Bakardjiev A . Tissue barriers of the human placenta to infection with Toxoplasma gondii. Infect Immun. 2011; 80(1):418-28. PMC: 3255695. DOI: 10.1128/IAI.05899-11. View

14.

Cunningham S, Hackstein H . Recent Advances in Good Manufacturing Practice-Grade Generation of Dendritic Cells. Transfus Med Hemother. 2021; 47(6):454-463. PMC: 7768120. DOI: 10.1159/000512451. View

15.

Philbin V, Dowling D, Gallington L, Cortes G, Tan Z, Suter E . Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways. J Allergy Clin Immunol. 2012; 130(1):195-204.e9. PMC: 3387351. DOI: 10.1016/j.jaci.2012.02.042. View

16.

Gonzalez A, Rebmann V, LeMaoult J, Horn P, Carosella E, Alegre E . The immunosuppressive molecule HLA-G and its clinical implications. Crit Rev Clin Lab Sci. 2012; 49(3):63-84. DOI: 10.3109/10408363.2012.677947. View

17.

Haas K, Poe J, Steeber D, Tedder T . B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae. Immunity. 2005; 23(1):7-18. DOI: 10.1016/j.immuni.2005.04.011. View

18.

STEIN K . Thymus-independent and thymus-dependent responses to polysaccharide antigens. J Infect Dis. 1992; 165 Suppl 1:S49-52. DOI: 10.1093/infdis/165-supplement_1-s49. View

19.

Heinemann A, Pirr S, Fehlhaber B, Mellinger L, Burgmann J, Busse M . In neonates S100A8/S100A9 alarmins prevent the expansion of a specific inflammatory monocyte population promoting septic shock. FASEB J. 2016; 31(3):1153-1164. DOI: 10.1096/fj.201601083R. View

20.

Zinkernagel R . Maternal antibodies, childhood infections, and autoimmune diseases. N Engl J Med. 2002; 345(18):1331-5. DOI: 10.1056/NEJMra012493. View