Molecular Genetics in Neuroblastoma Prognosis

Overview

Journal Children (Basel)

Specialty Health Services

Date 2021 Jun 2

PMID 34072462

Citations 10

Authors

Margherita Lerone

Marzia Ognibene

Annalisa Pezzolo

Giuseppe Martucciello

Federico Zara

Martina Morini

Katia Mazzocco

Affiliations

Soon will be listed here.

Abstract

In recent years, much research has been carried out to identify the biological and genetic characteristics of the neuroblastoma (NB) tumor in order to precisely define the prognostic subgroups for improving treatment stratification. This review will describe the major genetic features and the recent scientific advances, focusing on their impact on diagnosis, prognosis, and therapeutic solutions in NB clinical management.

Citing Articles

A comprehensive overview of liquid biopsy applications in pediatric solid tumors.

Janssen F, Lak N, Janda C, Kester L, Meister M, Merks J NPJ Precis Oncol. 2024; 8(1):172.

PMID: 39097671 PMC: 11297996. DOI: 10.1038/s41698-024-00657-z.

Application of the FISH method and high-density SNP arrays to assess genetic changes in neuroblastoma-research by one institute.

Winnicka D, Skowera P, Stelmach M, Styka B, Lejman M Acta Biochim Pol. 2024; 71:12821.

PMID: 39049899 PMC: 11267511. DOI: 10.3389/abp.2024.12821.

The Neuroblastoma Microenvironment, Heterogeneity and Immunotherapeutic Approaches.

Polychronopoulos P, Bedoya-Reina O, Johnsen J Cancers (Basel). 2024; 16(10).

PMID: 38791942 PMC: 11119056. DOI: 10.3390/cancers16101863.

Image-defined risk factors associated with MYCN oncogene amplification in neuroblastoma and their association with overall survival.

Wang H, Li T, Ni X, Chen X, He L, Cai J Abdom Radiol (NY). 2024; 49(6):1949-1960.

PMID: 38436700 DOI: 10.1007/s00261-024-04196-w.

Plasma-Derived Exosome Proteins as Novel Diagnostic and Prognostic Biomarkers in Neuroblastoma Patients.

Morini M, Raggi F, Bartolucci M, Petretto A, Ardito M, Rossi C Cells. 2023; 12(21).

PMID: 37947594 PMC: 10649754. DOI: 10.3390/cells12212516.

References

Pandey G, Mitra S, Subhash S, Hertwig F, Kanduri M, Mishra K . The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation. Cancer Cell. 2014; 26(5):722-37. DOI: 10.1016/j.ccell.2014.09.014. View

Russell M, Penikis A, Oldridge D, Alvarez-Dominguez J, McDaniel L, Diamond M . CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus. Cancer Res. 2015; 75(15):3155-66. PMC: 4526355. DOI: 10.1158/0008-5472.CAN-14-3613. View

Fardin P, Barla A, Mosci S, Rosasco L, Verri A, Versteeg R . A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients. Mol Cancer. 2010; 9:185. PMC: 2908582. DOI: 10.1186/1476-4598-9-185. View

He J, Gu L, Zhang H, Zhou M . Crosstalk between MYCN and MDM2-p53 signal pathways regulates tumor cell growth and apoptosis in neuroblastoma. Cell Cycle. 2011; 10(17):2994-3002. PMC: 3218600. DOI: 10.4161/cc.10.17.17118. View

Knezevich S, Garnett M, Pysher T, Beckwith J, Grundy P, Sorensen P . ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma. Cancer Res. 1998; 58(22):5046-8. View

Ognibene M, Morini M, Garaventa A, Podesta M, Pezzolo A . Identification of a minimal region of loss on chromosome 6q27 associated with poor survival of high-risk neuroblastoma patients. Cancer Biol Ther. 2020; 21(5):391-399. PMC: 7515498. DOI: 10.1080/15384047.2019.1704122. View

Szewczyk K, Wieczorek A, Mlynarski W, Janczar S, Woszczyk M, Gamrot Z . Unfavorable Outcome of Neuroblastoma in Patients With 2p Gain. Front Oncol. 2019; 9:1018. PMC: 6794702. DOI: 10.3389/fonc.2019.01018. View

Otto T, Horn S, Brockmann M, Eilers U, Schuttrumpf L, Popov N . Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. Cancer Cell. 2008; 15(1):67-78. DOI: 10.1016/j.ccr.2008.12.005. View

Nakagawara A, Li Y, Izumi H, Muramori K, Inada H, Nishi M . Neuroblastoma. Jpn J Clin Oncol. 2018; 48(3):214-241. DOI: 10.1093/jjco/hyx176. View

10.

Mosse Y, Laudenslager M, Longo L, Cole K, Wood A, Attiyeh E . Identification of ALK as a major familial neuroblastoma predisposition gene. Nature. 2008; 455(7215):930-5. PMC: 2672043. DOI: 10.1038/nature07261. View

11.

Barr E, Applebaum M . Genetic Predisposition to Neuroblastoma. Children (Basel). 2018; 5(9). PMC: 6162470. DOI: 10.3390/children5090119. View

12.

Javanmardi N, Fransson S, Djos A, Umapathy G, Ostensson M, Milosevic J . Analysis of ALK, MYCN, and the ALK ligand ALKAL2 (FAM150B/AUGα) in neuroblastoma patient samples with chromosome arm 2p rearrangements. Genes Chromosomes Cancer. 2019; 59(1):50-57. DOI: 10.1002/gcc.22790. View

13.

Challagundla K, Wise P, Neviani P, Chava H, Murtadha M, Xu T . Exosome-mediated transfer of microRNAs within the tumor microenvironment and neuroblastoma resistance to chemotherapy. J Natl Cancer Inst. 2015; 107(7). PMC: 4651042. DOI: 10.1093/jnci/djv135. View

14.

Thery C, Zitvogel L, Amigorena S . Exosomes: composition, biogenesis and function. Nat Rev Immunol. 2002; 2(8):569-79. DOI: 10.1038/nri855. View

15.

Lozier A, Rich M, Grawe A, Peck A, Zhao P, Chang A . Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma. Oncotarget. 2014; 6(1):196-206. PMC: 4381588. DOI: 10.18632/oncotarget.2768. View

16.

Schleiermacher G, Janoueix-Lerosey I, Ribeiro A, Klijanienko J, Couturier J, Pierron G . Accumulation of segmental alterations determines progression in neuroblastoma. J Clin Oncol. 2010; 28(19):3122-30. DOI: 10.1200/JCO.2009.26.7955. View

17.

Bailey S, Murnane J . Telomeres, chromosome instability and cancer. Nucleic Acids Res. 2006; 34(8):2408-17. PMC: 1458522. DOI: 10.1093/nar/gkl303. View

18.

Tolbert V, Matthay K . Neuroblastoma: clinical and biological approach to risk stratification and treatment. Cell Tissue Res. 2018; 372(2):195-209. PMC: 5918153. DOI: 10.1007/s00441-018-2821-2. View

19.

Cimmino F, Formicola D, Capasso M . Dualistic Role of BARD1 in Cancer. Genes (Basel). 2018; 8(12). PMC: 5748693. DOI: 10.3390/genes8120375. View

20.

Diskin S, Capasso M, Schnepp R, Cole K, Attiyeh E, Hou C . Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma. Nat Genet. 2012; 44(10):1126-30. PMC: 3459292. DOI: 10.1038/ng.2387. View