DNA Protection by an Aronia Juice-Based Food Supplement

Overview

Journal Antioxidants (Basel)

Date 2021 Jun 2

PMID 34071817

Citations 4

Authors

Tamara Bakuradze

Peter Meiser

Jens Galan

Elke Richling

Affiliations

Soon will be listed here.

Abstract

Background: This study investigated the effects of an aronia juice-based food supplement on background and total DNA strand breaks in whole blood, and on HO-induced DNA strand breaks in isolated peripheral blood lymphocytes.

Methods: Ninety-one healthy volunteers were randomly selected to consume either the food supplement (2 × 25 mL drinking ampules, = 45) or no supplement ( = 46) daily for eight weeks.

Results: Background DNA strand breaks decreased significantly after four and eight weeks of supplement consumption, compared to baseline ( < 0.05), but the overall effect was low, and neither group showed a decrease in total DNA strand breaks. Conversely, supplement consumption clearly reduced HO-induced DNA strand breaks ex vivo ( < 0.001), with statistically significant reductions after four and eight weeks, compared to the control group ( < 0.05).

Conclusions: Thus, although consuming antioxidant supplements might produce only marginal immediate benefits under healthy conditions, potential preventive effects warrant further investigation.

Citing Articles

Influence of Bilberry Extract on Neuronal Cell Toxicity.

Konig S, Bakuradze T, Jesser S, Ashoka Sreeja H, Carlsson M, Fahrer J Biology (Basel). 2024; 13(6).

PMID: 38927256 PMC: 11200780. DOI: 10.3390/biology13060376.

Effects of Chokeberries ( spp.) on Cytoprotective and Cardiometabolic Markers and Semen Quality in 109 Mildly Hypercholesterolemic Danish Men: A Prospective, Double-Blinded, Randomized, Crossover Trial.

Sangild J, Faldborg A, Schousboe C, Fedder M, Christensen L, Lausdahl A J Clin Med. 2023; 12(1).

PMID: 36615174 PMC: 9821700. DOI: 10.3390/jcm12010373.

Polyphenol-Rich Beverage Consumption Affecting Parameters of the Lipid Metabolism in Healthy Subjects.

Rahn C, Bakuradze T, Stegmuller S, Galan J, Niesen S, Winterhalter P Int J Mol Sci. 2023; 24(1).

PMID: 36614281 PMC: 9821765. DOI: 10.3390/ijms24010841.

Fractionation of Extracts from Black Chokeberry, Cranberry, and Pomegranate to Identify Compounds That Influence Lipid Metabolism.

Niesen S, Gottel C, Becker H, Bakuradze T, Winterhalter P, Richling E Foods. 2022; 11(4).

PMID: 35206045 PMC: 8871205. DOI: 10.3390/foods11040570.

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