Epidemiology, Genetic Characterization, and Evolution of Carried by and : The First Epidemiological Evidence from Southern China

Overview

Journal Pathogens

Date 2021 Jun 2

PMID 34071186

Citations 7

Authors

Minyi Zhang

Qiushuang Li

Fei Wu

Zejin Ou

Yongzhi Li

Fangfei You

Qing Chen

Affiliations

Soon will be listed here.

Abstract

is a novel member of the family . A single species, , is currently described. However, there is limited information on the identification of to date, and thereby the circulation of is not fully understood. Thus, the objective of this study was to investigate the prevalence, genomic characteristics, and evolution of rat hunnivirus in southern China. A total of 404 fecal samples were subjected to detection of from urban rats ( and ) using PCR assay based on specific primers targeted to partial 3D regions, with the prevalence of 17.8% in and 15.6% in . An almost full-length rat hunnivirus sequence (RatHuV/YY12/CHN) and the genome structure were acquired in the present study. Phylogenetic analysis of the P1 coding regions suggested the RatHuV/YY12/CHN sequence was found to be within the genotype of . The negative selection was further identified based on analysis of non-synonymous to synonymous substitution rates. The present findings suggest that hunniviruses are common in urban rats. Further research is needed for increased surveillance and awareness of potential risks to human health.

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