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LTBP4 in Health and Disease

Overview
Journal Genes (Basel)
Publisher MDPI
Date 2021 Jun 2
PMID 34071145
Citations 10
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Abstract

Latent transforming growth factor β (TGFβ)-binding protein (LTBP) 4, a member of the LTBP family, shows structural homology with fibrillins. Both these protein types are characterized by calcium-binding epidermal growth factor-like repeats interspersed with 8-cysteine domains. Based on its domain composition and distribution, LTBP4 is thought to adopt an extended structure, facilitating the linear deposition of tropoelastin onto microfibrils. In humans, mutations in LTBP4 result in autosomal recessive cutis laxa type 1C, characterized by redundant skin, pulmonary emphysema, and valvular heart disease. LTBP4 is an essential regulator of TGFβ signaling and is related to development, immunity, injury repair, and diseases, playing a central role in regulating inflammation, fibrosis, and cancer progression. In this review, we focus on medical disorders or diseases that may be manipulated by LTBP4 in order to enhance the understanding of this protein.

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References
1.
Yuan X, Downing A, Knott V, Handford P . Solution structure of the transforming growth factor beta-binding protein-like module, a domain associated with matrix fibrils. EMBO J. 1998; 16(22):6659-66. PMC: 1170270. DOI: 10.1093/emboj/16.22.6659. View

2.
Su C, Huang J, Chiang C, Lawrence E, Levine K, Dabovic B . Latent transforming growth factor binding protein 4 regulates transforming growth factor beta receptor stability. Hum Mol Genet. 2015; 24(14):4024-36. PMC: 4476448. DOI: 10.1093/hmg/ddv139. View

3.
Robertson I, Rifkin D . Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins. Cold Spring Harb Perspect Biol. 2016; 8(6). PMC: 4888822. DOI: 10.1101/cshperspect.a021907. View

4.
Zhang Y . Non-Smad Signaling Pathways of the TGF-β Family. Cold Spring Harb Perspect Biol. 2016; 9(2). PMC: 5287080. DOI: 10.1101/cshperspect.a022129. View

5.
Dabovic B, Chen Y, Colarossi C, Zambuto L, Obata H, Rifkin D . Bone defects in latent TGF-beta binding protein (Ltbp)-3 null mice; a role for Ltbp in TGF-beta presentation. J Endocrinol. 2002; 175(1):129-41. DOI: 10.1677/joe.0.1750129. View