Low Immunogenicity of Intravesical Phage Therapy for Urogenitary Tract Infections

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2021 Jun 2

PMID 34070276

Citations 9

Authors

Slawomir Letkiewicz

Marzanna Lusiak-Szelachowska

Ryszard Miedzybrodzki

Maciej Zaczek

Beata Weber-Dabrowska

Andrzej Gorski

Affiliations

Soon will be listed here.

Abstract

Patients with chronic urinary and urogenital multidrug resistant bacterial infections received phage therapy (PT) using intravesical or intravesical and intravaginal phage administration. A single course of PT did not induce significant serum antibody responses against administered phage. Whilst the second cycle of PT caused a significant increase in antibody levels, they nevertheless remained quite low. These data combined with good therapy results achieved in some patients suggest that this mode of PT may be an efficient means of therapy for urogenital infections and a reliable model for a clinical trial of PT.

Citing Articles

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