Assessment of Mini-Tablets Coating Uniformity As a Function of Fluid Bed Coater Inlet Conditions

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2021 Jun 2

PMID 34070006

Citations 3

Authors

Magdalena Turk

Rok Sibanc

Rok Dreu

Maja Frankiewicz

Malgorzata Sznitowska

Affiliations

Soon will be listed here.

Abstract

This study concerned the quality of mini-tablets' coating uniformity obtained by either the bottom spray chamber with a classical Wurster distributor (CW) or a swirl distributor (SW). Mini-tablets with a diameter of 2.0, 2.5, and 3.0 mm were coated with hypromellose using two different inlet air distributors as well as inlet airflow rates (130 and 156 m/h). Tartrazine was used as a colorant in the coating layer and the coating uniformity was assessed by spectrophotometric analysis of solutions obtained after disintegration of the mini-tablets (n = 100). Higher uniformity of coating material distribution among the mini-tablets was observed in the case of SW distributor, even for the biggest mini-tablets (d = 3.0 mm), with an RSD no larger than 5.0%. Additionally, coating thickness was evaluated by colorimetric analysis (n = 1000), using a scanner method, and expressed as a hue value. A high correlation (R = 0.993) between inter-tablet variability of hue and UV-Vis results was obtained. Mini-tablets were successfully coated in a fluid bed system using both a classical Wurster distributor as well as a swirl generator. However, regardless of the mini-tablets' diameter, better film uniformity was achieved in the case of a distributor with a swirl generator.

Citing Articles

The Effect of Design and Size of the Fluid-Bed Equipment on the Particle Size-Dependent Trend of Particle Coating Thickness and Drug Prolonged-Release Profile.

Brezovar T, Hudovornik G, Perpar M, Lustrik M, Dreu R AAPS PharmSciTech. 2023; 24(4):93.

PMID: 37002451 DOI: 10.1208/s12249-023-02540-9.

Review on Starter Pellets: Inert and Functional Cores.

Kallai-Szabo N, Lengyel M, Farkas D, Barna A, Fleck C, Basa B Pharmaceutics. 2022; 14(6).

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Development of Nanocrystal Compressed Minitablets for Chronotherapeutic Drug Delivery.

Sreeharsha N, Raghavendra Naveen N, Anitha P, Goudanavar P, Ramkanth S, Fattepur S Pharmaceuticals (Basel). 2022; 15(3).

PMID: 35337109 PMC: 8950040. DOI: 10.3390/ph15030311.

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