δ-Catenin Participates in EGF/AKT/p21 Signaling and Induces Prostate Cancer Cell Proliferation and Invasion

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Jun 2

PMID 34069970

Citations 11

Authors

Yingjie Shen

Hyoung Jae Lee

Rui Zhou

Hangun Kim

Gen Chen

Young-Chang Cho

Kwonseop Kim

Affiliations

Soon will be listed here.

Abstract

Prostate cancer (PCa) is the second most leading cause of death in males. Our previous studies have demonstrated that δ-catenin plays an important role in prostate cancer progression. However, the molecular mechanism underlying the regulation of δ-catenin has not been fully explored yet. In the present study, we found that δ-catenin could induce phosphorylation of p21 and stabilize p21 in the cytoplasm, thus blocking its nuclear accumulation for the first time. We also found that δ-catenin could regulate the interaction between AKT and p21, leading to phosphorylation of p21 at Thr-145 residue. Finally, EGF was found to be a key factor upstream of AKT/δ-catenin/p21 for promoting proliferation and metastasis in prostate cancer. Our findings provide new insights into molecular controls of EGF and the development of potential therapeutics targeting δ-catenin to control prostate cancer progression.

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References

He Y, Kim H, Ryu T, Kang Y, Kim J, Kim B . δ-Catenin overexpression promotes angiogenic potential of CWR22Rv-1 prostate cancer cells via HIF-1α and VEGF. FEBS Lett. 2012; 587(2):193-9. DOI: 10.1016/j.febslet.2012.11.024. View

Ashkenazi H, Cao X, Motola S, Popliker M, Conti M, Tsafriri A . Epidermal growth factor family members: endogenous mediators of the ovulatory response. Endocrinology. 2004; 146(1):77-84. DOI: 10.1210/en.2004-0588. View

Nascimento-Viana J, Alcantara-Hernandez R, Oliveira-Barros E, Castello Branco L, Feijo P, Romeiro L . The α1-adrenoceptor-mediated human hyperplastic prostate cells proliferation is impaired by EGF receptor inhibition. Life Sci. 2019; 239:117048. DOI: 10.1016/j.lfs.2019.117048. View

Wang Y, Fisher J, Mathew R, Ou L, Otieno S, Sublet J . Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21. Nat Chem Biol. 2011; 7(4):214-21. PMC: 3124363. DOI: 10.1038/nchembio.536. View

Fitzmaurice C, Dicker D, Pain A, Hamavid H, Moradi-Lakeh M, MacIntyre M . The Global Burden of Cancer 2013. JAMA Oncol. 2015; 1(4):505-27. PMC: 4500822. DOI: 10.1001/jamaoncol.2015.0735. View

Lu Q, Dobbs L, Gregory C, Lanford G, Revelo M, Shappell S . Increased expression of delta-catenin/neural plakophilin-related armadillo protein is associated with the down-regulation and redistribution of E-cadherin and p120ctn in human prostate cancer. Hum Pathol. 2005; 36(10):1037-48. DOI: 10.1016/j.humpath.2005.07.012. View

Zeng Y, Abdallah A, Lu J, Wang T, Chen Y, Terrian D . delta-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles. Mol Cancer. 2009; 8:19. PMC: 2660279. DOI: 10.1186/1476-4598-8-19. View

Liu Z, Chen X, Song H, Wang H, Zhang G, Wang H . Snail regulated by PKC/GSK-3β pathway is crucial for EGF-induced epithelial-mesenchymal transition (EMT) of cancer cells. Cell Tissue Res. 2014; 358(2):491-502. DOI: 10.1007/s00441-014-1953-2. View

Shrestha N, Shrestha H, Ryu T, Kim H, Simkhada S, Cho Y . δ-Catenin Increases the Stability of EGFR by Decreasing c-Cbl Interaction and Enhances EGFR/Erk1/2 Signaling in Prostate Cancer. Mol Cells. 2018; 41(4):320-330. PMC: 5935102. DOI: 10.14348/molcells.2018.2292. View

10.

Hsieh Y, Hwu L, Chen Y, Ke C, Chen F, Wang H . P21-driven multifusion gene system for evaluating the efficacy of histone deacetylase inhibitors by in vivo molecular imaging and for transcription targeting therapy of cancer mediated by histone deacetylase inhibitor. J Nucl Med. 2014; 55(4):678-85. DOI: 10.2967/jnumed.113.126573. View

11.

Prives C, Gottifredi V . The p21 and PCNA partnership: a new twist for an old plot. Cell Cycle. 2008; 7(24):3840-6. DOI: 10.4161/cc.7.24.7243. View

12.

He Y, Ryu T, Shrestha N, Yuan T, Kim H, Shrestha H . Interaction of EGFR to δ-catenin leads to δ-catenin phosphorylation and enhances EGFR signaling. Sci Rep. 2016; 6:21207. PMC: 4756308. DOI: 10.1038/srep21207. View

13.

Kim K, Oh M, Ki H, Wang T, Bareiss S, Fini M . Identification of E2F1 as a positive transcriptional regulator for delta-catenin. Biochem Biophys Res Commun. 2008; 369(2):414-20. PMC: 2614404. DOI: 10.1016/j.bbrc.2008.02.069. View

14.

Burger M, Tebay M, Keith P, Samaratunga H, Clements J, Lavin M . Expression analysis of delta-catenin and prostate-specific membrane antigen: their potential as diagnostic markers for prostate cancer. Int J Cancer. 2002; 100(2):228-37. DOI: 10.1002/ijc.10468. View

15.

Chen R, Thorner J . Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae. Biochim Biophys Acta. 2007; 1773(8):1311-40. PMC: 2031910. DOI: 10.1016/j.bbamcr.2007.05.003. View

16.

Oh M, Kim H, Yang I, Park J, Cong W, Baek M . GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis. J Biol Chem. 2009; 284(42):28579-89. PMC: 2781401. DOI: 10.1074/jbc.M109.002659. View

17.

Morton J, Jamieson N, Karim S, Athineos D, Ridgway R, Nixon C . LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest. Gastroenterology. 2010; 139(2):586-97, 597.e1-6. PMC: 3770904. DOI: 10.1053/j.gastro.2010.04.055. View

18.

Wang X, Zhu Y, Sun C, Wang T, Shen Y, Cai W . Feedback Activation of Basic Fibroblast Growth Factor Signaling via the Wnt/β-Catenin Pathway in Skin Fibroblasts. Front Pharmacol. 2017; 8:32. PMC: 5289949. DOI: 10.3389/fphar.2017.00032. View

19.

Siegel R, Miller K, Jemal A . Cancer statistics, 2020. CA Cancer J Clin. 2020; 70(1):7-30. DOI: 10.3322/caac.21590. View

20.

Yang I, Chang O, Lu Q, Kim K . Delta-catenin affects the localization and stability of p120-catenin by competitively interacting with E-cadherin. Mol Cells. 2010; 29(3):233-7. PMC: 3918506. DOI: 10.1007/s10059-010-0030-2. View