Sexual Dimorphism of Corticosteroid Signaling During Kidney Development

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Jun 2

PMID 34069759

Citations 1

Authors

Margaux Laulhe

Laurence Dumeige

Thi An Vu

Imene Hani

Eric Pussard

Marc Lombes

Say Viengchareun

Laetitia Martinerie

Affiliations

Soon will be listed here.

Abstract

Sexual dimorphism involves differences between biological sexes that go beyond sexual characteristics. In mammals, differences between sexes have been demonstrated regarding various biological processes, including blood pressure and predisposition to develop hypertension early in adulthood, which may rely on early events during development and in the neonatal period. Recent studies suggest that corticosteroid signaling pathways (comprising glucocorticoid and mineralocorticoid signaling pathways) have distinct tissue-specific expression and regulation during this specific temporal window in a sex-dependent manner, most notably in the kidney. This review outlines the evidence for a gender differential expression and activation of renal corticosteroid signaling pathways in the mammalian fetus and neonate, from mouse to human, that may favor mineralocorticoid signaling in females and glucocorticoid signaling in males. Determining the effects of such differences may shed light on short term and long term pathophysiological consequences, markedly for males.

Citing Articles

Effects of the environment on the evolution of the vertebrate urinary tract.

V Wiener S Nat Rev Urol. 2023; 20(12):719-738.

PMID: 37443264 DOI: 10.1038/s41585-023-00794-3.

References

Cheung J, Smith D . Molecular chaperone interactions with steroid receptors: an update. Mol Endocrinol. 2000; 14(7):939-46. DOI: 10.1210/mend.14.7.0489. View

Nicolaides N, Charmandari E . Chrousos syndrome: from molecular pathogenesis to therapeutic management. Eur J Clin Invest. 2015; 45(5):504-14. DOI: 10.1111/eci.12426. View

Lema I, Amazit L, Lamribet K, Fagart J, Blanchard A, Lombes M . HuR-Dependent Editing of a New Mineralocorticoid Receptor Splice Variant Reveals an Osmoregulatory Loop for Sodium Homeostasis. Sci Rep. 2017; 7(1):4835. PMC: 5500589. DOI: 10.1038/s41598-017-04838-8. View

Ishimoto H, Jaffe R . Development and function of the human fetal adrenal cortex: a key component in the feto-placental unit. Endocr Rev. 2010; 32(3):317-55. PMC: 3365797. DOI: 10.1210/er.2010-0001. View

Lu N, Cidlowski J . Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes. Mol Cell. 2005; 18(3):331-42. DOI: 10.1016/j.molcel.2005.03.025. View

Gumz M, Stow L, Lynch I, Greenlee M, Rudin A, Cain B . The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice. J Clin Invest. 2009; 119(8):2423-34. PMC: 2719945. DOI: 10.1172/JCI36908. View

Patel S, Dressler G . The genetics and epigenetics of kidney development. Semin Nephrol. 2013; 33(4):314-26. PMC: 3767926. DOI: 10.1016/j.semnephrol.2013.05.004. View

Kanashiro-Takeuchi R, Heidecker B, Lamirault G, Dharamsi J, Hare J . Sex-specific impact of aldosterone receptor antagonism on ventricular remodeling and gene expression after myocardial infarction. Clin Transl Sci. 2010; 2(2):134-42. PMC: 2805249. DOI: 10.1111/j.1752-8062.2009.00094.x. View

Mathai S, Derraik J, Cutfield W, Dalziel S, Harding J, Biggs J . Blood pressure abnormalities in adults born moderately preterm and their children. Int J Cardiol. 2014; 181:152-4. DOI: 10.1016/j.ijcard.2014.11.162. View

10.

Wiinberg N, Hoegholm A, Christensen H, Bang L, Mikkelsen K, Nielsen P . 24-h ambulatory blood pressure in 352 normal Danish subjects, related to age and gender. Am J Hypertens. 1995; 8(10 Pt 1):978-86. DOI: 10.1016/0895-7061(95)00216-2. View

11.

Grigore D, Ojeda N, Alexander B . Sex differences in the fetal programming of hypertension. Gend Med. 2008; 5 Suppl A:S121-32. PMC: 2657344. DOI: 10.1016/j.genm.2008.03.012. View

12.

White P . Alterations of Cortisol Metabolism in Human Disorders. Horm Res Paediatr. 2018; 89(5):320-330. DOI: 10.1159/000485508. View

13.

Lou Y, Zhang F, Luo Y, Wang L, Huang S, Jin F . Serum and Glucocorticoid Regulated Kinase 1 in Sodium Homeostasis. Int J Mol Sci. 2016; 17(8). PMC: 5000704. DOI: 10.3390/ijms17081307. View

14.

Veiras L, Girardi A, Curry J, Pei L, Ralph D, Tran A . Sexual Dimorphic Pattern of Renal Transporters and Electrolyte Homeostasis. J Am Soc Nephrol. 2017; 28(12):3504-3517. PMC: 5698077. DOI: 10.1681/ASN.2017030295. View

15.

Denic A, Mathew J, Lerman L, Lieske J, Larson J, Alexander M . Single-Nephron Glomerular Filtration Rate in Healthy Adults. N Engl J Med. 2017; 376(24):2349-2357. PMC: 5664219. DOI: 10.1056/NEJMoa1614329. View

16.

Battarbee A, Glover A, Vladutiu C, Gyamfi-Bannerman C, Aliaga S, Manuck T . Sex-Specific Differences in Late Preterm Neonatal Outcomes. Am J Perinatol. 2019; 36(12):1223-1228. DOI: 10.1055/s-0039-1683886. View

17.

Hilliard L, Sampson A, Brown R, Denton K . The "his and hers" of the renin-angiotensin system. Curr Hypertens Rep. 2012; 15(1):71-9. DOI: 10.1007/s11906-012-0319-y. View

18.

Manalich R, Reyes L, Herrera M, Melendi C, Fundora I . Relationship between weight at birth and the number and size of renal glomeruli in humans: a histomorphometric study. Kidney Int. 2000; 58(2):770-3. DOI: 10.1046/j.1523-1755.2000.00225.x. View

19.

Funder J, Pearce P, Smith R, Smith A . Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. Science. 1988; 242(4878):583-5. DOI: 10.1126/science.2845584. View

20.

Woolf A, Winyard P . Molecular mechanisms of human embryogenesis: developmental pathogenesis of renal tract malformations. Pediatr Dev Pathol. 2002; 5(2):108-29. DOI: 10.1007/s10024001-0141-z. View