Replication of Influenza A Virus in Secondary Lymphatic Tissue Contributes to Innate Immune Activation

Overview

Journal Pathogens

Date 2021 Jun 2

PMID 34069514

Authors

Sarah-Kim Friedrich

Rosa Schmitz

Michael Bergerhausen

Judith Lang

Vikas Duhan

Cornelia Hardt

Matthias Tenbusch

Marco Prinz

Kenichi Asano

Hilal Bhat

Thamer A Hamdan

Philipp Alexander Lang

Karl Sebastian Lang

Affiliations

Soon will be listed here.

Abstract

The replication of viruses in secondary lymphoid organs guarantees sufficient amounts of pattern-recognition receptor ligands and antigens to activate the innate and adaptive immune system. Viruses with broad cell tropism usually replicate in lymphoid organs; however, whether a virus with a narrow tropism relies on replication in the secondary lymphoid organs to activate the immune system remains not well studied. In this study, we used the artificial intravenous route of infection to determine whether Influenza A virus (IAV) replication can occur in secondary lymphatic organs (SLO) and whether such replication correlates with innate immune activation. Indeed, we found that IAV replicates in secondary lymphatic tissue. IAV replication was dependent on the expression of Sialic acid residues in antigen-presenting cells and on the expression of the interferon-inhibitor UBP43 (). The replication of IAV correlated with innate immune activation, resulting in IAV eradication. The genetic deletion of curbed IAV replication and limited innate immune activation. In conclusion, we found that IAV replicates in SLO, a mechanism which allows innate immune activation.

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