Delivery Systems of Retinoprotective Proteins in the Retina

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Jun 2

PMID 34069505

Citations 7

Authors

Ivan T Rebustini

Alexandra Bernardo-Colon

Alejandra Isasi Nalvarte

S Patricia Becerra

Affiliations

Soon will be listed here.

Abstract

Retinoprotective proteins play important roles for retinal tissue integrity. They can directly affect the function and the survival of photoreceptors, and/or indirectly target the retinal pigment epithelium (RPE) and endothelial cells that support these tissues. Retinoprotective proteins are used in basic, translational and in clinical studies to prevent and treat human retinal degenerative disorders. In this review, we provide an overview of proteins that protect the retina and focus on pigment epithelium-derived factor (PEDF), and its effects on photoreceptors, RPE cells, and endothelial cells. We also discuss delivery systems such as pharmacologic and genetic administration of proteins to achieve photoreceptor survival and retinal tissue integrity.

Citing Articles

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Yang Y, Wen W, Chen F, Zhang Y, Liu X, Yang X World J Gastrointest Oncol. 2024; 16(3):670-686.

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