Chronic Obstructive Pulmonary Disease Patients' Acceptance in E-Health Clinical Trials

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2021 Jun 2

PMID 34069028

Citations 13

Authors

Saeed M Alghamdi

Ahmed M Al Rajah

Yousef S Aldabayan

Abdulelah M Aldhahir

Jaber S Alqahtani

Abdulaziz A Alzahrani

Affiliations

Soon will be listed here.

Abstract

Introduction: Telehealth (TH) interventions with Chronic Obstructive Pulmonary Disease (COPD) management were introduced in the literature more than 20 years ago with different labeling, but there was no summary for the overall acceptance and dropout rates as well as associated variables.

Objective: This review aims to summarize the acceptance and dropout rates used in TH interventions and identify to what extent clinical settings, sociodemographic factors, and intervention factors might impact the overall acceptance and completion rates of TH interventions.

Methods: We conducted a systematic search up to April 2021 on CINAHL, PubMed, MEDLINE (Ovid), Cochrane, Web of Sciences, and Embase to retrieve randomized and non-randomized control trials that provide TH interventions alone or accompanied with other interventions to individuals with COPD.

Results: Twenty-seven studies met the inclusion criteria. Overall, the unweighted average of acceptance and dropout rates for all included studies were 80% and 19%, respectively. A meta-analysis on the pooled difference between the acceptance rates and dropout rates (weighted by the sample size) revealed a significant difference in acceptance and dropout rates among all TH interventions 51% (95% CI 49% to 52; < 0.001) and 63% (95% CI 60% to 67; < 0.001), respectively. Analysis revealed that acceptance and dropout rates can be impacted by trial-related, sociodemographic, and intervention-related variables. The most common reasons for dropouts were technical difficulties (33%), followed by complicated system (31%).

Conclusions: Current TH COPD interventions have a pooled acceptance rate of 51%, but this is accompanied by a high dropout rate of 63%. Acceptance and dropout levels in TH clinical trials can be affected by sociodemographic and intervention-related factors. This knowledge enlightens designs for well-accepted future TH clinical trials. PROSPERO registration number CRD4201707854.

Citing Articles

Efficacy and Acceptability of a Mobile App for Monitoring the Clinical Status of Patients With Chronic Obstructive Pulmonary Disease Receiving Home Oxygen Therapy: Randomized Controlled Trial.

Naranjo-Rojas A, Perula-de Torres L, Cruz-Mosquera F, Molina-Recio G J Med Internet Res. 2025; 27():e65888.

PMID: 39761550 PMC: 11747540. DOI: 10.2196/65888.

Unveiling the Influence of AI on Advancements in Respiratory Care: Narrative Review.

Alqahtani M, Alanazi A, Algarni S, Aljohani H, Alenezi F, Alotaibi T Interact J Med Res. 2024; 13:e57271.

PMID: 39705080 PMC: 11699506. DOI: 10.2196/57271.

Tracking Real-World Physical Activity in Chronic Obstructive Pulmonary Disease Over One Year: Results from a Monocentric, Prospective, Observational Cohort Study.

Boesch M, Baty F, Bilz S, Brutsche M, Rassouli F Int J Chron Obstruct Pulmon Dis. 2024; 19:1921-1929.

PMID: 39219563 PMC: 11365517. DOI: 10.2147/COPD.S469984.

Addressing Barriers to Chronic Obstructive Pulmonary Disease (COPD) Care: Three Innovative Evidence-Based Approaches: A Review.

Siu D, Gafni-Lachter L Int J Chron Obstruct Pulmon Dis. 2024; 19:331-341.

PMID: 38317666 PMC: 10843977. DOI: 10.2147/COPD.S426050.

Enrollment and dropout rates of individuals with chronic obstructive pulmonary disease approached for telehealth interventions: A systematic review and meta-regression analysis.

Alhasani R, Janaudis Ferreira T, Valois M, Singh D, Ahmed S Heliyon. 2024; 10(1):e23776.

PMID: 38230240 PMC: 10789598. DOI: 10.1016/j.heliyon.2023.e23776.

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