Incorporation of Copper-Doped Mesoporous Bioactive Glass Nanospheres in Experimental Dental Composites: Chemical and Mechanical Characterization

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2021 Jun 2

PMID 34067788

Citations 13

Authors

Danijela Marovic

Havard J Haugen

Visnja Negovetic Mandic

Matej Par

Kai Zheng

Zrinka Tarle

Aldo R Boccaccini

Affiliations

Soon will be listed here.

Abstract

Experimental dental resin composites incorporating copper-doped mesoporous bioactive glass nanospheres (Cu-MBGN) were designed to impart antibacterial and remineralizing properties. The study evaluated the influence of Cu-MBGN on the mechanical properties and photopolymerization of resin composites. Cu-MBGN were synthesized using a microemulsion-assisted sol-gel method. Increasing amounts of Cu-MBGN (0, 1, 5, and 10 wt %) were added to the organic polymer matrix with inert glass micro- and nanofillers while maintaining a constant resin/filler ratio. Six tests were performed: X-ray diffraction, scanning electron microscopy, flexural strength (FS), flexural modulus (FM), Vickers microhardness (MH), and degree of conversion (DC). FS and MH of Cu-MBGN composites with silica fillers showed no deterioration with aging, with statistically similar results at 1 and 28 days. FM was not influenced by the addition of Cu-MBGN but was reduced for all tested materials after 28 days. The specimens with 1 and 5% Cu-MBGN had the highest FS, FM, MH, and DC values at 28 days, while controls with 45S5 bioactive glass had the lowest FM, FS, and MH. DC was high for all materials (83.7-93.0%). Cu-MBGN composites with silica have a potential for clinical implementation due to high DC and good mechanical properties with adequate resistance to aging.

Citing Articles

Microstructure, wear, and corrosion properties of PEEK-based composite coating incorporating titania- and copper-doped mesoporous bioactive glass nanoparticles.

Ahmad K, Imran A, Minhas B, Aizaz A, Khaliq A, Wadood A RSC Adv. 2025; 15(3):1856-1877.

PMID: 39839236 PMC: 11748198. DOI: 10.1039/d4ra07986h.

Engineering mesoporous bioactive glasses for emerging stimuli-responsive drug delivery and theranostic applications.

Cui Y, Hong S, Jiang W, Li X, Zhou X, He X Bioact Mater. 2024; 34:436-462.

PMID: 38282967 PMC: 10821497. DOI: 10.1016/j.bioactmat.2024.01.001.

Water-Induced Changes in Experimental Resin Composites Functionalized with Conventional (45S5) and Customized Bioactive Glass.

Muradbegovic A, Par M, Panduric V, Zugec P, Taubock T, Attin T J Funct Biomater. 2023; 14(6).

PMID: 37367262 PMC: 10298865. DOI: 10.3390/jfb14060298.

Antibacterial and Antibiofilm Efficacy of Copper-Doped Phosphate Glass on Pathogenic Bacteria.

Shetty S, Sekar P, Shetty R, Abou Neel E Molecules. 2023; 28(7).

PMID: 37049941 PMC: 10096066. DOI: 10.3390/molecules28073179.

Mesoporous Bioactive Nanoparticles for Bone Tissue Applications.

Arcos D, Portoles M Int J Mol Sci. 2023; 24(4).

PMID: 36834659 PMC: 9964985. DOI: 10.3390/ijms24043249.

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