» Articles » PMID: 34066191

Lingonberry ( L.) Fruit As a Source of Bioactive Compounds with Health-Promoting Effects-A Review

Overview
Journal Int J Mol Sci
Publisher MDPI
Date 2021 Jun 2
PMID 34066191
Citations 31
Authors
Affiliations
Soon will be listed here.
Abstract

Berries, especially members of the Ericaceae family, are among the best dietary sources of bioactive compounds with beneficial health effects. The most popular berries are in the genus , such as bilberry (), cranberry (, ), and blueberry (). Lingonberry () is less prevalent in the daily human diet because they are collected from the wild, and plant breeding of lingonberry is still on a small scale. Lingonberries are classed as "superfruits" with the highest content of antioxidants among berries and a broad range of health-promoting effects. Many studies showed various beneficial effects of lingonberries, such as anti-inflammatory, antioxidant, and anticancer activities. Lingonberries have been shown to prevent low-grade inflammation and diet-induced obesity in diabetic animals. Moreover, lingonberry intake has been associated with a beneficial effect on preventing and treating brain aging and neurodegenerative disorders. The consumption of berries and their health-promoting activity is a subject receiving a great deal of attention. Many studies investigated the natural compounds found in berries to combat diseases and promote healthy aging. This article's scope is to indicate the potential beneficial effect of lingonberry consumption on health, to promote well-being and longevity.

Citing Articles

Revealing Lingonberry's Neuroprotective Potential in Alzheimer's Disease Through Network Pharmacology and Molecular Docking.

Li J, Wang M, Wang Y, Peng X, Lv G, Zheng T Int J Mol Sci. 2025; 26(5).

PMID: 40076984 PMC: 11899733. DOI: 10.3390/ijms26052363.


Edible Berries-An Update on Nutritional Composition and Health Benefits-Part II.

Thorakkattu P, Jain S, Sivapragasam N, Maurya A, Tiwari S, Dwivedy A Curr Nutr Rep. 2025; 14(1):10.

PMID: 39753836 DOI: 10.1007/s13668-024-00608-x.


Valorization of Bioactive Compounds from Lingonberry Pomace and Grape Pomace with Antidiabetic Potential.

Neagu E, Paun G, Albu C, Radu G Molecules. 2024; 29(22).

PMID: 39598832 PMC: 11597371. DOI: 10.3390/molecules29225443.


A Review on the Protecting Effects and Molecular Mechanisms of Berries Against a Silent Public Health Concern: Non-Alcoholic Fatty Liver Disease.

Sharma A, Lee H Antioxidants (Basel). 2024; 13(11).

PMID: 39594531 PMC: 11590959. DOI: 10.3390/antiox13111389.


Distinct microbial communities associated with health-relevant wild berries.

Vepstaite-Monstavice I, Luksa J, Strazdaite-Zieliene Z, Serva S, Serviene E Environ Microbiol Rep. 2024; 16(6):e70048.

PMID: 39540551 PMC: 11561701. DOI: 10.1111/1758-2229.70048.


References
1.
Kylli P, Nohynek L, Puupponen-Pimia R, Westerlund-Wikstrom B, Leppanen T, Welling J . Lingonberry (Vaccinium vitis-idaea) and European cranberry (Vaccinium microcarpon) proanthocyanidins: isolation, identification, and bioactivities. J Agric Food Chem. 2011; 59(7):3373-84. DOI: 10.1021/jf104621e. View

2.
Reichert K, Schetinger M, Gutierres J, Pelinson L, Stefanello N, Dalenogare D . Lingonberry Extract Provides Neuroprotection by Regulating the Purinergic System and Reducing Oxidative Stress in Diabetic Rats. Mol Nutr Food Res. 2018; 62(16):e1800050. DOI: 10.1002/mnfr.201800050. View

3.
Lehtonen H, Lindstedt A, Jarvinen R, Sinkkonen J, Graca G, Viitanen M . 1H NMR-based metabolic fingerprinting of urine metabolites after consumption of lingonberries (Vaccinium vitis-idaea) with a high-fat meal. Food Chem. 2013; 138(2-3):982-90. DOI: 10.1016/j.foodchem.2012.10.081. View

4.
Mane C, Loonis M, Juhel C, Dufour C, Malien-Aubert C . Food grade lingonberry extract: polyphenolic composition and in vivo protective effect against oxidative stress. J Agric Food Chem. 2011; 59(7):3330-9. DOI: 10.1021/jf103965b. View

5.
Misikangas M, Pajari A, Paivarinta E, Oikarinen S, Rajakangas J, Marttinen M . Three Nordic berries inhibit intestinal tumorigenesis in multiple intestinal neoplasia/+ mice by modulating beta-catenin signaling in the tumor and transcription in the mucosa. J Nutr. 2007; 137(10):2285-90. DOI: 10.1093/jn/137.10.2285. View