Dietary Intake of Vitamin E and Fats Associated with Sarcopenia in Community-Dwelling Older Japanese People: A Cross-Sectional Study from the Fifth Survey of the ROAD Study

Overview

Journal Nutrients

Date 2021 Jun 2

PMID 34065253

Citations 12

Authors

Yuta Otsuka

Toshiko Iidaka

Chiaki Horii

Shigeyuki Muraki

Hiroyuki Oka

Kozo Nakamura

Takayuki Izumo

Tomohiro Rogi

Hiroshi Shibata

Sakae Tanaka

Noriko Yoshimura

Affiliations

Soon will be listed here.

Abstract

Dietary habits are of considerable interest as a modifiable factor for the maintenance of muscle health, especially sarcopenia. The present study aimed to investigate the association between dietary intake and sarcopenia prevalence in community-dwelling Japanese subjects. This cross-sectional study was conducted using data from the fifth survey of the Research on Osteoarthritis/Osteoporosis against Disability (ROAD) study, and 1345 participants (437 men and 908 women) aged ≥60 years were included in the analysis. Sarcopenia was determined by the definition of the Asian Working Group for Sarcopenia established in 2014, and dietary intake was assessed with the brief-type self-administered diet history questionnaire. Overall, 77 subjects (5.7%) were identified as having sarcopenia, 5.0% of men and 6.1% of women. Multiple logistic regression analysis showed that the odds ratios of sarcopenia for the dietary intake of vitamin E (α-tocopherol, 0.14 (CI 0.04-0.49), β-tocopherol (0.24, CI 0.07-0.78), γ-tocopherol (0.28, CI 0.09-0.87), and fats (fat 0.27, CI 0.08-0.96; monounsaturated fatty acids, 0.22, CI 0.07-0.72, polyunsaturated fatty acids, 0.28, CI 0.09-0.89) at the highest quantile were significantly lower compared with those at the lowest quantile. Therefore, higher dietary intakes of vitamin E and fats would be associated with a lower prevalence of sarcopenia.

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References

Chen L, Woo J, Assantachai P, Auyeung T, Chou M, Iijima K . Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment. J Am Med Dir Assoc. 2020; 21(3):300-307.e2. DOI: 10.1016/j.jamda.2019.12.012. View

Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K . Exercise habits during middle age are associated with lower prevalence of sarcopenia: the ROAD study. Osteoporos Int. 2013; 25(3):1081-8. DOI: 10.1007/s00198-013-2550-z. View

Servais S, Letexier D, Favier R, Duchamp C, Desplanches D . Prevention of unloading-induced atrophy by vitamin E supplementation: links between oxidative stress and soleus muscle proteolysis?. Free Radic Biol Med. 2007; 42(5):627-35. PMC: 1913194. DOI: 10.1016/j.freeradbiomed.2006.12.001. View

Welch A, Jennings A, Kelaiditi E, Skinner J, Steves C . Cross-Sectional Associations Between Dietary Antioxidant Vitamins C, E and Carotenoid Intakes and Sarcopenic Indices in Women Aged 18-79 Years. Calcif Tissue Int. 2019; 106(4):331-342. PMC: 7072069. DOI: 10.1007/s00223-019-00641-x. View

. American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. Med Sci Sports Exerc. 2009; 41(3):687-708. DOI: 10.1249/MSS.0b013e3181915670. View

Niki E . Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence. Free Radic Biol Med. 2013; 66:3-12. DOI: 10.1016/j.freeradbiomed.2013.03.022. View

Dong X, Xing Q, Li Y, Han X, Sun L . Dexmedetomidine protects against ischemia-reperfusion injury in rat skeletal muscle. J Surg Res. 2013; 186(1):240-5. DOI: 10.1016/j.jss.2013.07.052. View

Veronese N, Stubbs B, Punzi L, Soysal P, Antonelli Incalzi R, Saller A . Effect of nutritional supplementations on physical performance and muscle strength parameters in older people: A systematic review and meta-analysis. Ageing Res Rev. 2019; 51:48-54. DOI: 10.1016/j.arr.2019.02.005. View

Mareschal J, Genton L, Collet T, Graf C . Nutritional Intervention to Prevent the Functional Decline in Community-Dwelling Older Adults: A Systematic Review. Nutrients. 2020; 12(9). PMC: 7551991. DOI: 10.3390/nu12092820. View

10.

Mori H, Tokuda Y . Differences and overlap between sarcopenia and physical frailty in older community-dwelling Japanese. Asia Pac J Clin Nutr. 2019; 28(1):157-165. DOI: 10.6133/apjcn.201903_28(1).0021. View

11.

Yoshimura N, Muraki S, Oka H, Iidaka T, Kodama R, Kawaguchi H . Is osteoporosis a predictor for future sarcopenia or vice versa? Four-year observations between the second and third ROAD study surveys. Osteoporos Int. 2016; 28(1):189-199. DOI: 10.1007/s00198-016-3823-0. View

12.

Aragno M, Mastrocola R, Catalano M, Brignardello E, Danni O, Boccuzzi G . Oxidative stress impairs skeletal muscle repair in diabetic rats. Diabetes. 2004; 53(4):1082-8. DOI: 10.2337/diabetes.53.4.1082. View

13.

Muraki S, Oka H, Akune T, Mabuchi A, En-Yo Y, Yoshida M . Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts: the ROAD study. Osteoarthritis Cartilage. 2009; 17(9):1137-43. DOI: 10.1016/j.joca.2009.04.005. View

14.

Dreyer H, Drummond M, Pennings B, Fujita S, Glynn E, Chinkes D . Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle. Am J Physiol Endocrinol Metab. 2007; 294(2):E392-400. PMC: 2706121. DOI: 10.1152/ajpendo.00582.2007. View

15.

Marcos-Pardo P, Gonzalez-Galvez N, Lopez-Vivancos A, Espeso-Garcia A, Martinez-Aranda L, Gea-Garcia G . Sarcopenia, Diet, Physical Activity and Obesity in European Middle-Aged and Older Adults: The LifeAge Study. Nutrients. 2020; 13(1). PMC: 7822002. DOI: 10.3390/nu13010008. View

16.

Muraki S, Akune T, En-yo Y, Yoshida M, Tanaka S, Kawaguchi H . Association of dietary intake with joint space narrowing and osteophytosis at the knee in Japanese men and women: the ROAD study. Mod Rheumatol. 2014; 24(2):236-42. DOI: 10.3109/14397595.2013.854055. View

17.

Sasaki S, Yanagibori R, Amano K . Self-administered diet history questionnaire developed for health education: a relative validation of the test-version by comparison with 3-day diet record in women. J Epidemiol. 1998; 8(4):203-15. DOI: 10.2188/jea.8.203. View

18.

Chen L, Liu L, Woo J, Assantachai P, Auyeung T, Bahyah K . Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc. 2014; 15(2):95-101. DOI: 10.1016/j.jamda.2013.11.025. View

19.

Kim I, Schutzler S, Schrader A, Spencer H, Kortebein P, Deutz N . Quantity of dietary protein intake, but not pattern of intake, affects net protein balance primarily through differences in protein synthesis in older adults. Am J Physiol Endocrinol Metab. 2014; 308(1):E21-8. PMC: 4280213. DOI: 10.1152/ajpendo.00382.2014. View

20.

Li C, Kang B, Zhang T, Gu H, Song P, Chen J . Dietary Pattern and Dietary Energy from Fat Associated with Sarcopenia in Community-Dwelling Older Chinese People: A Cross-Sectional Study in Three Regions of China. Nutrients. 2020; 12(12). PMC: 7760936. DOI: 10.3390/nu12123689. View