Pediatric Rhabdomyosarcoma: Epidemiology and Genetic Susceptibility

Overview

Journal J Clin Med

Specialty General Medicine

Date 2021 Jun 2

PMID 34065162

Citations 25

Authors

Bailey A Martin-Giacalone

P Adam Weinstein

Sharon E Plon

Philip J Lupo

Affiliations

Soon will be listed here.

Abstract

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children, yet little is known about its etiology. Studies that examine either environmental exposures or germline genetic predisposition in RMS have begun to identify factors that contribute to this malignancy. Here, we summarize epidemiological reports of RMS incidence in terms of several factors, including age at diagnosis, biological sex, and geographic location. We then describe findings from association studies, which explore the role of parental exposures, birth and perinatal characteristics, and childhood exposures in RMS. Further, we discuss RMS predisposition syndromes and large-scale sequencing studies that have further identified RMS-associated genes. Finally, we propose future directions of study, which aim to advance our understanding of the origin of RMS and can provide knowledge for novel RMS therapies.

Citing Articles

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