Correlation Between Liver Stiffness by Two-Dimensional Shear Wave Elastography and Waist Circumference in Japanese Local Citizens with Abdominal Obesity

Overview

Journal J Clin Med

Specialty General Medicine

Date 2021 Jun 2

PMID 34064337

Citations 2

Authors

Tomoki Miyoshi

Masahide Hamaguchi

Noriyuki Kitagawa

Yoshitaka Hashimoto

Michiaki Fukui

Affiliations

Soon will be listed here.

Abstract

Background: Various factors other than fibrosis could affect liver stiffness (LS), measured by two-dimensional shear wave elastography (2D-SWE). We aimed to clarify the factors affecting LS in local citizens.

Methods: We performed a cross-sectional study among local citizens of a health checkup program. Abdominal obesity was defined as waist circumference ≥85 cm for men and ≥90 cm for women. We evaluated the correlation between LS by 2D-SWE (Aplio 500) and waist circumference with linear regression analyses. We selected the following items as variables in the multivariate analysis: waist circumference, sex, hypertension, diabetes, diagnostic components of metabolic syndrome, γ-glutamyl transpeptidase, total bilirubin, NAFLD fibrosis score, and an indicator of a fatty liver, evaluated ultrasonographically.

Results: Overall, 345 individuals were included; 318 (181 men and 137 women; age, 63.4 years; waist circumference, 84.0 cm; LS, 5.79 kPa) were analyzed, 128 of whom had abdominal obesity and significantly higher LS than non-abdominally obese individuals. In the multivariate analysis, waist circumference was positively, independently, and significantly correlated with LS only in abdominally obese individuals.

Conclusions: Liver stiffness by 2D-SWE could increase with increases in waist circumference in local citizens with abdominal obesity. Physicians should pay attention when assessing the LS of abdominally obese individuals.

Citing Articles

Non-invasive Assessment of Liver Fibrosis Using Shear Wave Elastography in Patients With Type 2 Diabetes Mellitus Having Non-alcoholic Fatty Liver Disease.

Arun Kumar D, Kumar S, Rajagopal R, Ramesh R, M M Cureus. 2024; 16(10):e72471.

PMID: 39600758 PMC: 11590170. DOI: 10.7759/cureus.72471.

Ultrasound-Based Hepatic Elastography in Non-Alcoholic Fatty Liver Disease: Focus on Patients with Type 2 Diabetes.

Cazac G, Lacatusu C, Mihai C, Grigorescu E, Onofriescu A, Mihai B Biomedicines. 2022; 10(10).

PMID: 36289643 PMC: 9598125. DOI: 10.3390/biomedicines10102375.

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