Regulation of Death Receptor Signaling by S-Palmitoylation and Detergent-Resistant Membrane Micro Domains-Greasing the Gears of Extrinsic Cell Death Induction, Survival, and Inflammation
Overview
Affiliations
Death-receptor-mediated signaling results in either cell death or survival. Such opposite signaling cascades emanate from receptor-associated signaling complexes, which are often formed in different subcellular locations. The proteins involved are frequently post-translationally modified (PTM) by ubiquitination, phosphorylation, or glycosylation to allow proper spatio-temporal regulation/recruitment of these signaling complexes in a defined cellular compartment. During the last couple of years, increasing attention has been paid to the reversible cysteine-centered PTM S-palmitoylation. This PTM regulates the hydrophobicity of soluble and membrane proteins and modulates protein:protein interaction and their interaction with distinct membrane micro-domains (i.e., lipid rafts). We conclude with which functional and mechanistic roles for S-palmitoylation as well as different forms of membrane micro-domains in death-receptor-mediated signal transduction were unraveled in the last two decades.
Balasubramanian A, Hsu A, Ghimire L, Tahir M, Devant P, Fontana P Sci Immunol. 2024; 9(94):eadn1452.
PMID: 38530158 PMC: 11367861. DOI: 10.1126/sciimmunol.adn1452.
Yuan Y, Li P, Li J, Zhao Q, Chang Y, He X Signal Transduct Target Ther. 2024; 9(1):60.
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Grisanti L Front Physiol. 2023; 14:1256852.
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Hong K, Yang Q, Yin H, Zhang J, Yu B Open Life Sci. 2023; 18(1):20220630.
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Liu Q, Fang L, Gao C, Liu C, Yu H, Wu J Biomed Res Int. 2022; 2022:1371315.
PMID: 36277882 PMC: 9581708. DOI: 10.1155/2022/1371315.