Ex Vivo Mesenchymal Stem Cell Therapy to Regenerate Machine Perfused Organs

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Jun 2

PMID 34063399

Citations 7

Authors

Christina Bogensperger

Julia Hofmann

Franka Messner

Thomas Resch

Andras Meszaros

Benno Cardini

Annemarie Weissenbacher

Rupert Oberhuber

Jakob Troppmair

Dietmar Ofner

Stefan Schneeberger

Theresa Hautz

Affiliations

Soon will be listed here.

Abstract

Transplantation represents the treatment of choice for many end-stage diseases but is limited by the shortage of healthy donor organs. Ex situ normothermic machine perfusion (NMP) has the potential to extend the donor pool by facilitating the use of marginal quality organs such as those from donors after cardiac death (DCD) and extended criteria donors (ECD). NMP provides a platform for organ quality assessment but also offers the opportunity to treat and eventually regenerate organs during the perfusion process prior to transplantation. Due to their anti-inflammatory, immunomodulatory and regenerative capacity, mesenchymal stem cells (MSCs) are considered as an interesting tool in this model system. Only a limited number of studies have reported on the use of MSCs during ex situ machine perfusion so far with a focus on feasibility and safety aspects. At this point, no clinical benefits have been conclusively demonstrated, and studies with controlled transplantation set-ups are urgently warranted to elucidate favorable effects of MSCs in order to improve organs during ex situ machine perfusion.

Citing Articles

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