Molecular Analysis of Hemoglobin H Disease in Taiwan
Overview
Affiliations
The molecular basis of seven Chinese patients in Taiwan with hemoglobin H disease was investigated and was found to be heterogeneous in the mutation type. They were alpha-thalassemia-1 mutation combined with hemoglobin Constant Spring, an undetermined nondeletion form of alpha-thalassemia and a deletion form of alpha-thalassemia-2 mutations. The alpha-thalassemia-1 mutation was shown to be the --SEA type I haplotype.
Rapid molecular characterization of Hb H disease in Chinese by polymerase chain reaction.
Chang J, Liu T, Perng L, Chiou S, Chen T, Chen P Ann Hematol. 1994; 68(1):33-7.
PMID: 8110877 DOI: 10.1007/BF01695917.
Rapid detection of -alpha 4.2 deletion of alpha-thalassemia-2 by polymerase chain reaction.
Chang J, Liu T, Chiou S, Chen J, Chen T, Lin C Ann Hematol. 1994; 69(4):205-9.
PMID: 7948308 DOI: 10.1007/BF02215955.