Oxidative Modifications of RNA and Its Potential Roles in Biosystem

Overview

Journal Front Mol Biosci

Specialty Biology

Date 2021 May 31

PMID 34055897

Citations 23

Authors

Mikiei Tanaka

P Boon Chock

Affiliations

Soon will be listed here.

Abstract

Elevated level of oxidized RNA was detected in vulnerable neurons in Alzheimer patients. Subsequently, several diseases and pathological conditions were reported to be associated with RNA oxidation. In addition to several oxidized derivatives, cross-linking and unique strand breaks are generated by RNA oxidation. With a premise that dysfunctional RNA mediated by oxidation is the pathogenetic molecular mechanism, intensive investigations have revealed the mechanism for translation errors, including premature termination, which gives rise to aberrant polypeptides. To this end, we and others revealed that mRNA oxidation could compromise its translational activity and fidelity. Under certain conditions, oxidized RNA can also induce several signaling pathways, to mediate inflammatory response and induce apoptosis. In this review, we focus on the oxidative modification of RNA and its resulting effect on protein synthesis as well as cell signaling. In addition, we will also discuss the potential roles of enzymatic oxidative modification of RNA in mediating cellular effects.

Citing Articles

Production, Isolation, and Characterization of Stable Isotope-Labeled Standards for Mass Spectrometric Measurements of Oxidatively-Damaged Nucleosides in RNA.

Jaruga P, Kant M, Dizdaroglu M ACS Omega. 2025; 10(1):1519-1530.

PMID: 39829548 PMC: 11740632. DOI: 10.1021/acsomega.4c09310.

RNA Stability: A Review of the Role of Structural Features and Environmental Conditions.

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Mapping the future of oxidative RNA damage in neurodegeneration: Rethinking the status quo with new tools.

Wheeler H, Madrigal A, Chaim I Proc Natl Acad Sci U S A. 2024; 121(46):e2317860121.

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Ferroptosis induces nucleolar stress as revealed by live-cell imaging using thioflavin T.

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