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Artificial Intelligence for Clinical Decision Support in Sepsis

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Specialty General Medicine
Date 2021 May 31
PMID 34055839
Citations 16
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Abstract

Sepsis is one of the main causes of death in critically ill patients. Despite the continuous development of medical technology in recent years, its morbidity and mortality are still high. This is mainly related to the delay in starting treatment and non-adherence of clinical guidelines. Artificial intelligence (AI) is an evolving field in medicine, which has been used to develop a variety of innovative Clinical Decision Support Systems. It has shown great potential in predicting the clinical condition of patients and assisting in clinical decision-making. AI-derived algorithms can be applied to multiple stages of sepsis, such as early prediction, prognosis assessment, mortality prediction, and optimal management. This review describes the latest literature on AI for clinical decision support in sepsis, and outlines the application of AI in the prediction, diagnosis, subphenotyping, prognosis assessment, and clinical management of sepsis. In addition, we discussed the challenges of implementing and accepting this non-traditional methodology for clinical purposes.

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References
1.
Artigas L, Coma M, Matos-Filipe P, Aguirre-Plans J, Farres J, Valls R . In-silico drug repurposing study predicts the combination of pirfenidone and melatonin as a promising candidate therapy to reduce SARS-CoV-2 infection progression and respiratory distress caused by cytokine storm. PLoS One. 2020; 15(10):e0240149. PMC: 7531795. DOI: 10.1371/journal.pone.0240149. View

2.
Helguera-Repetto A, Soto-Ramirez M, Villavicencio-Carrisoza O, Yong-Mendoza S, Yong-Mendoza A, Leon-Juarez M . Neonatal Sepsis Diagnosis Decision-Making Based on Artificial Neural Networks. Front Pediatr. 2020; 8:525. PMC: 7518045. DOI: 10.3389/fped.2020.00525. View

3.
Ibrahim Z, Wu H, Hamoud A, Stappen L, Dobson R, Agarossi A . On classifying sepsis heterogeneity in the ICU: insight using machine learning. J Am Med Inform Assoc. 2020; 27(3):437-443. PMC: 7025363. DOI: 10.1093/jamia/ocz211. View

4.
Lee B, Kwon O, Park H, Cho K, Kwon J, Lee Y . Graph Convolutional Networks-Based Noisy Data Imputation in Electronic Health Record. Crit Care Med. 2020; 48(11):e1106-e1111. DOI: 10.1097/CCM.0000000000004583. View

5.
Perng J, Kao I, Kung C, Hung S, Lai Y, Su C . Mortality Prediction of Septic Patients in the Emergency Department Based on Machine Learning. J Clin Med. 2019; 8(11). PMC: 6912277. DOI: 10.3390/jcm8111906. View