Hippocampal Glycerol-3-Phosphate Acyltransferases 4 and BDNF in the Progress of Obesity-Induced Depression

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2021 May 31

PMID 34054732

Citations 8

Authors

Yin-Qiong Huang

Yaofeng Wang

Keyue Hu

Shu Lin

Xia-Hong Lin

Affiliations

Soon will be listed here.

Abstract

Background: Obesity has been reported to lead to increased incidence of depression. Glycerol-3-phosphate acyltransferases 4 (GPAT4) is involved in triacylglycerol synthesis and plays an important role in the occurrence of obesity. GPAT4 is the only one of GPAT family expressed in the brain. The aim of this study is to investigate if central GPAT4 is associated with obesity-related depression and its underlying mechanism.

Results: A high-fat diet resulted in increased body weight and blood lipid. HFD induced depression like behavior in the force swimming test, tail suspension test and sucrose preference test. HFD significantly up-regulated the expression of GPAT4 in hippocampus, IL-1β, IL-6, TNF-α and NF-κB, accompanied with down-regulation of BDNF expression in hippocampus and ventromedical hypothalamus, which was attributed to AMP-activated protein kinase (AMPK) and cAMP-response element binding protein (CREB).

Conclusion: Our findings suggest that hippocampal GPAT4 may participate in HFD induced depression through AMPK/CREB/BDNF pathway, which provides insights into a clinical target for obesity-associated depression intervention.

Citing Articles

The Wicked Relationship between Depression and Metabolic Syndrome.

Marazziti D, Arone A, Palermo S, Annuzzi E, Cappellato G, Chiarantini I Clin Neuropsychiatry. 2023; 20(2):100-108.

PMID: 37234360 PMC: 10206662. DOI: 10.36131/cnfioritieditore20230202.

Curcumin-dependent phenotypic transformation of microglia mediates resistance to pseudorabies-induced encephalitis.

Feng L, Luo G, Li Y, Zhang C, Liu Y, Liu Y Vet Res. 2023; 54(1):25.

PMID: 36918933 PMC: 10015794. DOI: 10.1186/s13567-023-01149-x.

E prostanoid receptor-3 promotes oxidized low-density lipoprotein-induced human aortic smooth muscle cells inflammation.

Hu C, Wang Y, Huang W, Xia Y ESC Heart Fail. 2022; 10(2):1077-1089.

PMID: 36578105 PMC: 10053191. DOI: 10.1002/ehf2.14264.

Molecular Mechanisms and Health Benefits of Ghrelin: A Narrative Review.

Jiao Z, Luo Q Nutrients. 2022; 14(19).

PMID: 36235843 PMC: 9572668. DOI: 10.3390/nu14194191.

Metabolic modeling-based drug repurposing in Glioblastoma.

Tomi-Andrino C, Pandele A, Winzer K, King J, Rahman R, Kim D Sci Rep. 2022; 12(1):11189.

PMID: 35778411 PMC: 9249780. DOI: 10.1038/s41598-022-14721-w.

References

Crowley J, Jones M, OLeary O, Lucki I . Automated tests for measuring the effects of antidepressants in mice. Pharmacol Biochem Behav. 2004; 78(2):269-74. DOI: 10.1016/j.pbb.2004.03.014. View

Masheb R, Grilo C, Rolls B . A randomized controlled trial for obesity and binge eating disorder: low-energy-density dietary counseling and cognitive-behavioral therapy. Behav Res Ther. 2011; 49(12):821-9. PMC: 3223390. DOI: 10.1016/j.brat.2011.09.006. View

Molendijk M, Spinhoven P, Polak M, Bus B, Penninx B, Elzinga B . Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484). Mol Psychiatry. 2013; 19(7):791-800. DOI: 10.1038/mp.2013.105. View

Pistell P, Morrison C, Gupta S, Knight A, Keller J, Ingram D . Cognitive impairment following high fat diet consumption is associated with brain inflammation. J Neuroimmunol. 2009; 219(1-2):25-32. PMC: 2823983. DOI: 10.1016/j.jneuroim.2009.11.010. View

Nibuya M, Morinobu S, Duman R . Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci. 1995; 15(11):7539-47. PMC: 6578063. View

Karth M, Baugher B, Daly N, Karth M, Gironda S, Sachs B . Brain 5-HT Deficiency Prevents Antidepressant-Like Effects of High-Fat-Diet and Blocks High-Fat-Diet-Induced GSK3β Phosphorylation in the Hippocampus. Front Mol Neurosci. 2020; 12:298. PMC: 6917648. DOI: 10.3389/fnmol.2019.00298. View

Savage J, St-Pierre M, Hui C, Tremblay M . Microglial Ultrastructure in the Hippocampus of a Lipopolysaccharide-Induced Sickness Mouse Model. Front Neurosci. 2020; 13:1340. PMC: 6932978. DOI: 10.3389/fnins.2019.01340. View

Gondoni L, Titon A, Silvestri G, Nibbio F, Taronna O, Ferrari P . Short term effects of physical exercise and low calorie diet on left ventricular function in obese subjects: a tissue Doppler study. Nutr Metab Cardiovasc Dis. 2006; 17(5):358-64. DOI: 10.1016/j.numecd.2006.01.013. View

Lopez M, Nogueiras R, Tena-Sempere M, Dieguez C . Hypothalamic AMPK: a canonical regulator of whole-body energy balance. Nat Rev Endocrinol. 2016; 12(7):421-32. DOI: 10.1038/nrendo.2016.67. View

10.

Raison C, Rutherford R, Woolwine B, Shuo C, Schettler P, Drake D . A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry. 2012; 70(1):31-41. PMC: 4015348. DOI: 10.1001/2013.jamapsychiatry.4. View

11.

Andre C, OConnor J, Kelley K, Lestage J, Dantzer R, Castanon N . Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration. J Neuroimmunol. 2008; 200(1-2):90-9. PMC: 2571040. DOI: 10.1016/j.jneuroim.2008.06.011. View

12.

Luppino F, de Wit L, Bouvy P, Stijnen T, Cuijpers P, Penninx B . Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry. 2010; 67(3):220-9. DOI: 10.1001/archgenpsychiatry.2010.2. View

13.

Tanaka S, Ide M, Shibutani T, Ohtaki H, Numazawa S, Shioda S . Lipopolysaccharide-induced microglial activation induces learning and memory deficits without neuronal cell death in rats. J Neurosci Res. 2006; 83(4):557-66. DOI: 10.1002/jnr.20752. View

14.

Herring M, Sailors M, Bray M . Genetic factors in exercise adoption, adherence and obesity. Obes Rev. 2013; 15(1):29-39. DOI: 10.1111/obr.12089. View

15.

Goshen I, Kreisel T, Ben-Menachem-Zidon O, Licht T, Weidenfeld J, Ben-Hur T . Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol Psychiatry. 2007; 13(7):717-28. DOI: 10.1038/sj.mp.4002055. View

16.

Kohler C, Freitas T, Stubbs B, Maes M, Solmi M, Veronese N . Peripheral Alterations in Cytokine and Chemokine Levels After Antidepressant Drug Treatment for Major Depressive Disorder: Systematic Review and Meta-Analysis. Mol Neurobiol. 2017; 55(5):4195-4206. DOI: 10.1007/s12035-017-0632-1. View

17.

Erion J, Wosiski-Kuhn M, Dey A, Hao S, Davis C, Pollock N . Obesity elicits interleukin 1-mediated deficits in hippocampal synaptic plasticity. J Neurosci. 2014; 34(7):2618-31. PMC: 3921429. DOI: 10.1523/JNEUROSCI.4200-13.2014. View

18.

Noble F, Rubira E, Boulanouar M, Palmier B, Plotkine M, Warnet J . Acute systemic inflammation induces central mitochondrial damage and mnesic deficit in adult Swiss mice. Neurosci Lett. 2007; 424(2):106-10. DOI: 10.1016/j.neulet.2007.07.005. View

19.

Chen Y, Kuo M, Li S, Bui H, Peake D, Sanders P . AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. J Biol Chem. 2008; 283(15):10048-57. PMC: 2442282. DOI: 10.1074/jbc.M708151200. View

20.

Stein S, Winnik S, Matter C . Brain-derived neurotrophic factor Val66Met polymorphism in depression and thrombosis: SIRT1 as a possible mediator. Eur Heart J. 2015; 38(18):1436-1438. DOI: 10.1093/eurheartj/ehv692. View