Cyclin E in Normal Physiology and Disease States

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2021 May 30

PMID 34052101

Citations 45

Authors

Chen Chu

Yan Geng

Yu Zhou

Piotr Sicinski

Affiliations

Soon will be listed here.

Abstract

E-type cyclins, collectively called cyclin E, represent key components of the core cell cycle machinery. In mammalian cells, two E-type cyclins, E1 and E2, activate cyclin-dependent kinase 2 (CDK2) and drive cell cycle progression by phosphorylating several cellular proteins. Abnormally elevated activity of cyclin E-CDK2 has been documented in many human tumor types. Moreover, cyclin E overexpression mediates resistance of tumor cells to various therapeutic agents. Recent work has revealed that the role of cyclin E extends well beyond cell proliferation and tumorigenesis, and it may regulate a diverse array of physiological and pathological processes. In this review, we discuss these various cyclin E functions and the potential for therapeutic targeting of cyclin E and cyclin E-CDK2 kinase.

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