Comparison of Del Nido Cardioplegia and Blood Cardioplegia in Terms of Development of Postoperative Atrial Fibrillation in Patients Undergoing Isolated Coronary Artery Bypass Grafting

Overview

Journal Braz J Cardiovasc Surg

Specialty Cardiology & Vascular Diseases

Date 2021 May 28

PMID 34048202

Citations 4

Authors

Umut Serhat Sanri

Kadir Kaan Ozsin

Faruk Toktas

Senol Yavuz

Affiliations

Soon will be listed here.

Abstract

Objective: Del Nido cardioplegia (DNC) has been used in pediatric cardiac surgery for many years with a single dose application and its usage in adult cardiac surgery has been increasing in recent years, with results being published. In this study, we aimed to investigate the effect of DNC on the development of postoperative atrial fibrillation (PoAF).

Methods: In this retrospective observational comparative study, 255 patients who underwent isolated on-pump coronary artery bypass grafting, between January 2019 and November 2019, were enrolled. The patients were divided into two groups: DNC (n=132) and blood cardioplegia (BC) (n=123). Intraoperative and postoperative data were evaluated and compared in terms of the development of PoAF.

Results: We found that the development of PoAF and the length of hospital stay remain significantly higher in the BC group (P=0.044, P<0.001, respectively). In addition, the aortic cross-clamp time and the cardioplegia volume delivered were significantly lower in the DNC group (P=0.042, P<0.001, respectively). In multivariate logistic regression analysis, only higher cardioplegia volume was determined as an independent predictor for PoAF development (OR 1.001; 95% CI 1.000-1.001; P=0.033). We did not found difference between groups in terms of troponin T, inotropic drug support, need for intraaortic balloon pump and mortality.

Conclusion: This study showed that DNC can be used safely in adult coronary bypass surgery and PoAF development effect is reduced.

Citing Articles

Del Nido vs. Cold Blood Cardioplegia for High-Risk Isolated Coronary Artery Bypass Grafting in Patients with Reduced Ventricular Function.

Sanetra K, Gerber W, Mazur M, Kubaszewska M, Pietrzyk E, Buszman P Braz J Cardiovasc Surg. 2024; 39(1):e20220346.

PMID: 38315052 PMC: 10836820. DOI: 10.21470/1678-9741-2022-0346.

Postoperative atrial fibrillation and coronary bypass graft surgery: like two peas in a pod.

Engin M, Kat N Rev Assoc Med Bras (1992). 2023; 70(1):e20231099.

PMID: 38126415 PMC: 10740185. DOI: 10.1590/1806-9282.20231099.

Outcomes of coronary artery bypass surgery using modified del Nido cardioplegia in patients with poor ventricular function.

Brown S, Nassar K, Razzouk J, Kashyap A, Won M, Shehadeh T J Cardiothorac Surg. 2023; 18(1):346.

PMID: 38031138 PMC: 10685478. DOI: 10.1186/s13019-023-02466-0.

Myocardial Protection in Isolated Coronary Artery Bypass Grafting: Del Nido versus Blood Cardioplegia.

Ozkara T, Kaygin M, Ergun S, Limandal H, Diler M, Dayi H Braz J Cardiovasc Surg. 2022; 38(2):259-264.

PMID: 36459478 PMC: 10069256. DOI: 10.21470/1678-9741-2022-0093.

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