The Disorders of Endometrial Receptivity in PCOS and Its Mechanisms

Overview

Journal Reprod Sci

Publisher Springer

Specialty Reproductive Medicine

Date 2021 May 28

PMID 34046867

Citations 26

Authors

Nan-Xing Jiang

Xue-Lian Li

Affiliations

Soon will be listed here.

Abstract

Polycystic ovary syndrome (PCOS) is a mysterious and complicated endocrine disease with the combination of metabolic, reproductive, psychological dysfunctions. Impaired endometrial receptivity and ovulation disorders/anovulation are both important causes of PCOS-related infertility. However, change in endometrium has never received the same attention as ovulatory dysfunction. Besides, putting emphasis on endometrial function may be more realistic for PCOS-related infertility, given the wide use of assisted reproductive technology. The present review focuses on the disorders of endometrial receptivity of patients with PCOS, summarizes the changes of the indicators of endometrial receptivity including leukemia inhibitory factor, homeobox genes A, pinopodes, αvβ3-integrin, and intercellular junctions and also analyzes the possible mechanisms of decreased endometrial receptivity and its relationship with the main endocrine and metabolic disorders of PCOS such as hyperandrogenism, inflammation, insulin resistance, and obesity. Despite several biomarkers have been found to be associated with decreased endometrial receptivity in PCOS, the clinical relevance of these findings still awaits future clarification.

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References

Bozdag G, Mumusoglu S, Zengin D, Karabulut E, Yildiz B . The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod. 2016; 31(12):2841-2855. DOI: 10.1093/humrep/dew218. View

Eden J . The polycystic ovary syndrome presenting as resistant acne successfully treated with cyproterone acetate. Med J Aust. 1991; 155(10):677-80. DOI: 10.5694/j.1326-5377.1991.tb93959.x. View

Ashkenazi J, Farhi J, Orvieto R, Homburg R, Dekel A, Feldberg D . Polycystic ovary syndrome patients as oocyte donors: the effect of ovarian stimulation protocol on the implantation rate of the recipient. Fertil Steril. 1995; 64(3):564-7. DOI: 10.1016/s0015-0282(16)57793-0. View

Wilcox A, Baird D, Weinberg C . Time of implantation of the conceptus and loss of pregnancy. N Engl J Med. 1999; 340(23):1796-9. DOI: 10.1056/NEJM199906103402304. View

Griffiths R, Pru C, Behura S, Cronrath A, McCallum M, Kelp N . AMPK is required for uterine receptivity and normal responses to steroid hormones. Reproduction. 2020; 159(6):707-717. PMC: 7259611. DOI: 10.1530/REP-19-0402. View

Paulson R . Introduction: Endometrial receptivity: evaluation, induction and inhibition. Fertil Steril. 2019; 111(4):609-610. DOI: 10.1016/j.fertnstert.2019.02.029. View

Tong R, Zhou Y, He Q, Zhuang Y, Zhou W, Xia F . Analysis of the guidance value of 3D ultrasound in evaluating endometrial receptivity for frozen-thawed embryo transfer in patients with repeated implantation failure. Ann Transl Med. 2020; 8(15):944. PMC: 7475420. DOI: 10.21037/atm-20-5463. View

Griesinger G, Trevisan S, Cometti B . Endometrial thickness on the day of embryo transfer is a poor predictor of IVF treatment outcome. Hum Reprod Open. 2019; 2018(1):hox031. PMC: 6276703. DOI: 10.1093/hropen/hox031. View

Diaz-Gimeno P, Ruiz-Alonso M, Blesa D, Bosch N, Martinez-Conejero J, Alama P . The accuracy and reproducibility of the endometrial receptivity array is superior to histology as a diagnostic method for endometrial receptivity. Fertil Steril. 2012; 99(2):508-17. DOI: 10.1016/j.fertnstert.2012.09.046. View

10.

Cozzolino M, Diaz-Gimeno P, Pellicer A, Garrido N . Evaluation of the endometrial receptivity assay and the preimplantation genetic test for aneuploidy in overcoming recurrent implantation failure. J Assist Reprod Genet. 2020; 37(12):2989-2997. PMC: 7714804. DOI: 10.1007/s10815-020-01948-7. View

11.

Craciunas L, Gallos I, Chu J, Bourne T, Quenby S, Brosens J . Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis. Hum Reprod Update. 2019; 25(2):202-223. DOI: 10.1093/humupd/dmy044. View

12.

Bhatt H, Brunet L, Stewart C . Uterine expression of leukemia inhibitory factor coincides with the onset of blastocyst implantation. Proc Natl Acad Sci U S A. 1991; 88(24):11408-12. PMC: 53144. DOI: 10.1073/pnas.88.24.11408. View

13.

Chen J, Cheng J, Shatzer T, Sewell L, Hernandez L, Stewart C . Leukemia inhibitory factor can substitute for nidatory estrogen and is essential to inducing a receptive uterus for implantation but is not essential for subsequent embryogenesis. Endocrinology. 2000; 141(12):4365-72. DOI: 10.1210/endo.141.12.7855. View

14.

Akbas G, Taylor H . HOXC and HOXD gene expression in human endometrium: lack of redundancy with HOXA paralogs. Biol Reprod. 2003; 70(1):39-45. DOI: 10.1095/biolreprod.102.014969. View

15.

Panzan M, Soares Junior J, Motta E, Haapalainen E, de Jesus Simoes M, Baptista H . Metoclopramide-induced hyperprolactinaemia caused marked decline in pinopodes and pregnancy rates in mice. Hum Reprod. 2006; 21(10):2514-20. DOI: 10.1093/humrep/del093. View

16.

Poon C, Madawala R, Dowland S, Murphy C . Nectin-3 Is Increased in the Cell Junctions of the Uterine Epithelium at Implantation. Reprod Sci. 2016; 23(11):1580-1592. DOI: 10.1177/1933719116648216. View

17.

Wu J, Taylor R, Sidell N . Retinoic acid regulates gap junction intercellular communication in human endometrial stromal cells through modulation of the phosphorylation status of connexin 43. J Cell Physiol. 2012; 228(4):903-10. DOI: 10.1002/jcp.24241. View

18.

Daftary G, Troy P, Bagot C, Young S, Taylor H . Direct regulation of beta3-integrin subunit gene expression by HOXA10 in endometrial cells. Mol Endocrinol. 2002; 16(3):571-9. DOI: 10.1210/mend.16.3.0792. View

19.

Rarani F, Borhani F, Rashidi B . Endometrial pinopode biomarkers: Molecules and microRNAs. J Cell Physiol. 2018; 233(12):9145-9158. DOI: 10.1002/jcp.26852. View

20.

Chung T, Park M, Kim H, Choi H, Ha K . Integrin αVβ3 and αVβ5 are required for leukemia inhibitory factor-mediated the adhesion of trophoblast cells to the endometrial cells. Biochem Biophys Res Commun. 2016; 469(4):936-40. DOI: 10.1016/j.bbrc.2015.12.103. View