» Articles » PMID: 34046336

The Choice of Candidates in Survival Markers Based on Coordinated Gene Expression in Renal Cancer

Overview
Journal Front Oncol
Specialty Oncology
Date 2021 May 28
PMID 34046336
Citations 4
Authors
Affiliations
Soon will be listed here.
Abstract

We aimed to identify and investigate genes that are essential for the development of clear cell renal cell carcinoma (ccRCC) and sought to shed light on the mechanisms of its progression and create prognostic markers for the disease. We used real-time PCR to study the expression of 20 genes that were preliminarily selected based on their differential expression in ccRCC, in 68 paired tumor/normal samples. Upon ccRCC progression, seven genes that showed an initial increase in expression showed decreased expression. The genes whose expression levels did not significantly change during progression were associated mainly with metabolic and inflammatory processes. The first group included , , , , , , and , whose expression levels were coordinately decreased during tumor progression. This expression coordination and gene function is related to the needs of tumor development at different stages. Specifically, the high correlation coefficient of and expression may indicate the importance of the coordinated regulation of glycolysis and mitochondrial metabolism. A panel of , , , and enabled the prediction of survival for more than 3.5 years in patients with ccRCC, with a probability close to 90%. Therefore, a coordinated change in the expression of a gene group during ccRCC progression was detected, and a new panel of markers for individual survival prognosis was identified.

Citing Articles

Angiopoietin-like protein 4 dysregulation in kidney diseases: a promising biomarker and therapeutic target.

Li Y, Zhang Y, Cao M, Yuan T, Ou S Front Pharmacol. 2025; 15():1475198.

PMID: 39840089 PMC: 11747783. DOI: 10.3389/fphar.2024.1475198.


BHLHE41, a transcriptional repressor involved in physiological processes and tumor development.

Bret C, Desmots-Loyer F, Moreaux J, Fest T Cell Oncol (Dordr). 2024; 48(1):43-66.

PMID: 39254779 PMC: 11850569. DOI: 10.1007/s13402-024-00973-3.


NXPH4 Promotes Gemcitabine Resistance in Bladder Cancer by Enhancing Reactive Oxygen Species and Glycolysis Activation through Modulating NDUFA4L2.

Wang D, Zhang P, Liu Z, Xing Y, Xiao Y Cancers (Basel). 2022; 14(15).

PMID: 35954445 PMC: 9367313. DOI: 10.3390/cancers14153782.


The multifaceted role of EGLN family prolyl hydroxylases in cancer: going beyond HIF regulation.

Strocchi S, Reggiani F, Gobbi G, Ciarrocchi A, Sancisi V Oncogene. 2022; 41(29):3665-3679.

PMID: 35705735 DOI: 10.1038/s41388-022-02378-8.


Panel of Candidate Genes to Predict the Survival of Patients with Clear Cell Renal Cancer on the Basis of Gene Expression Regulated by HIF1α/HIF2α.

Apanovich N, Apanovich P, Mansorunov D, Kuzevanova A, Korotaeva A, Bogush T Bull Exp Biol Med. 2022; 172(6):738-742.

PMID: 35501649 DOI: 10.1007/s10517-022-05468-5.

References
1.
Goel M, Khanna P, Kishore J . Understanding survival analysis: Kaplan-Meier estimate. Int J Ayurveda Res. 2011; 1(4):274-8. PMC: 3059453. DOI: 10.4103/0974-7788.76794. View

2.
Jager K, van Dijk P, Zoccali C, Dekker F . The analysis of survival data: the Kaplan-Meier method. Kidney Int. 2008; 74(5):560-5. DOI: 10.1038/ki.2008.217. View

3.
Bigot P, Colli L, Machiela M, Jessop L, Myers T, Carrouget J . Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41. Nat Commun. 2016; 7:12098. PMC: 4941055. DOI: 10.1038/ncomms12098. View

4.
Kaluz S, Kaluzova M, Liao S, Lerman M, Stanbridge E . Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9: A one transcription factor (HIF-1) show?. Biochim Biophys Acta. 2009; 1795(2):162-72. PMC: 2670353. DOI: 10.1016/j.bbcan.2009.01.001. View

5.
Shi S, Qin X, Wang S, Wang W, Zhu Y, Lin Y . Identification of potential novel differentially-expressed genes and their role in invasion and migration in renal cell carcinoma. Aging (Albany NY). 2020; 12(10):9205-9223. PMC: 7288970. DOI: 10.18632/aging.103192. View