IL-30 (IL-27A): a Familiar Stranger in Immunity, Inflammation, and Cancer

Overview

Journal Exp Mol Med

Specialties Biochemistry
Molecular Biology

Date 2021 May 28

PMID 34045653

Citations 7

Authors

Booki Min

Dongkyun Kim

Matthias J Feige

Affiliations

Soon will be listed here.

Abstract

Over the years, interleukin (IL)-27 has received much attention because of its highly divergent, sometimes even opposing, functions in immunity. IL-30, the p28 subunit that forms IL-27 together with Ebi3 and is also known as IL-27p28 or IL-27A, has been considered a surrogate to represent IL-27. However, it was later discovered that IL-30 can form complexes with other protein subunits, potentially leading to overlapping or discrete functions. Furthermore, there is emerging evidence that IL-30 itself may perform immunomodulatory functions independent of Ebi3 or other binding partners and that IL-30 production is strongly associated with certain cancers in humans. In this review, we will discuss the biology of IL-30 and other IL-30-associated cytokines and their functions in inflammation and cancer.

Citing Articles

Role of IL-27 in COVID-19: A Thin Line between Protection and Disease Promotion.

Korobova Z, Arsentieva N, Santoni A, Totolian A Int J Mol Sci. 2024; 25(14).

PMID: 39063193 PMC: 11276726. DOI: 10.3390/ijms25147953.

IL-30 protects against sepsis-induced myocardial dysfunction by inhibiting pro-inflammatory macrophage polarization and pyroptosis.

Zhao M, Zheng Z, Zhang P, Xu Y, Zhang J, Peng S iScience. 2023; 26(9):107544.

PMID: 37636037 PMC: 10450523. DOI: 10.1016/j.isci.2023.107544.

Cell type specific IL-27p28 (IL-30) deletion in mice uncovers an unexpected regulatory function of IL-30 in autoimmune inflammation.

Kim D, Kim S, Kang M, Yin Z, Min B Sci Rep. 2023; 13(1):1812.

PMID: 36725904 PMC: 9892501. DOI: 10.1038/s41598-023-27413-w.

Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27.

Skladanowska K, Bloch Y, Strand J, White K, Hua J, Aldridge D Cell Rep. 2022; 41(3):111490.

PMID: 36261006 PMC: 9597551. DOI: 10.1016/j.celrep.2022.111490.

Interleukin 27 Signaling in Rheumatoid Arthritis Patients: Good or Evil?.

Han L, Chen Z, Yu K, Yan J, Li T, Ba X Front Immunol. 2022; 12:787252.

PMID: 35058928 PMC: 8764250. DOI: 10.3389/fimmu.2021.787252.

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