Baroreceptor Inputs to the Nucleus Tractus Solitarius in the Cat: Postsynaptic Actions and the Influence of Respiration

Overview

Journal J Physiol

Specialty Physiology

Date 1988 May 1

PMID 3404463

Citations 23

Authors

S W Mifflin

K M Spyer

Affiliations

Soon will be listed here.

Abstract

1. The postsynaptic action of carotid sinus nerve (SN), aortic nerve (AN), superior laryngeal nerve (SLN) and vagal nerve (VN) stimulation has been studied on neurones in the nucleus of the tractus solitarius (NTS) in vivo. 2. Three distinct patterns of postsynaptic responses were evoked by SN stimulation, an EPSP, an EPSP-IPSP sequence and an IPSP, observed separately in individual neurones. This diversity of response was represented in cells proven to receive baroreceptor input by inflation of a balloon-tipped catheter within the ipsilateral carotid sinus. 3. Virtually none of the neurones identified as baroreceptive exhibited pulse-related discharge. 4. A variety of influences to AN, SLN and VN stimulation were observed in neurones receiving baroreceptor afferent information. This wide convergence of input implies that this region of the brain stem is important in the integration of cardiovascular reflexes. 5. The hypothesis was tested that respiratory 'gating' of the baroreceptor reflex is produced by synaptic actions within the NTS. There was an absence of any modification of PSPs by lung inflation and by variations in the timing of the stimulation of the afferent nerves within the respiratory cycle. These observations indicate that respiratory modifications of the baroreceptor reflex must occur at later stages in the reflex pathway.

Citing Articles

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References

RALL W, Burke R, Smith T, Nelson P, Frank K . Dendritic location of synapses and possible mechanisms for the monosynaptic EPSP in motoneurons. J Neurophysiol. 1967; 30(5):1169-93. DOI: 10.1152/jn.1967.30.5.1169. View

Jordan D, Mifflin S, Spyer K . Hypothalamic inhibition of neurones in the nucleus tractus solitarius of the cat is GABA mediated. J Physiol. 1988; 399:389-404. PMC: 1191671. DOI: 10.1113/jphysiol.1988.sp017087. View

BARILLOT J . [Primry afferent depolarization of vagal and laryngeal fibres. A unit study]. J Physiol (Paris). 1970; 62(3):273-94. View

BISCOE T, Sampson S . An analysis of the inhibition of phrenic motoneurones which occurs on stimulation of some cranial nerve afferents. J Physiol. 1970; 209(2):375-93. PMC: 1395745. DOI: 10.1113/jphysiol.1970.sp009170. View

Hildebrandt J . Central connections of aortic depressor and carotid sinus nerves. Exp Neurol. 1974; 45(3):590-605. DOI: 10.1016/0014-4886(74)90164-2. View

Langhorst P, Dittmar K, Camerer H . Facultative coupling of reticular neuronal activity with peripheral cardiovascular and central cortical rhythms. Brain Res. 1975; 87(2-3):407-18. DOI: 10.1016/0006-8993(75)90437-0. View

Lipski J, McAllen R, Spyer K . The sinus nerve and baroreceptor input to the medulla of the cat. J Physiol. 1975; 251(1):61-78. PMC: 1348376. DOI: 10.1113/jphysiol.1975.sp011081. View

Miura M . Postsynaptic potentials recorded from nucleus of the solitary tract and its subjacent reticular formation elicited by stimulation of the carotid sinus nerve. Brain Res. 1975; 100(2):437-40. DOI: 10.1016/0006-8993(75)90497-7. View

Davidson N, Goldner S, McCloskey D . Respiratory modulation of barareceptor and chemoreceptor reflexes affecting heart rate and cardiac vagal efferent nerve activity. J Physiol. 1976; 259(2):523-30. PMC: 1309043. DOI: 10.1113/jphysiol.1976.sp011480. View

10.

Jordan D, Spyer K . Studies on the excitability of sinus nerve afferent terminals. J Physiol. 1979; 297(0):123-34. PMC: 1458711. DOI: 10.1113/jphysiol.1979.sp013031. View

11.

Hotson J, Prince D . A calcium-activated hyperpolarization follows repetitive firing in hippocampal neurons. J Neurophysiol. 1980; 43(2):409-19. DOI: 10.1152/jn.1980.43.2.409. View

12.

Sypert G, Munson J, Fleshman J . Effect of presynaptic inhibition on axonal potentials, terminal potentials, focal synaptic potentials, and EPSPs in cat spinal cord. J Neurophysiol. 1980; 44(4):792-803. DOI: 10.1152/jn.1980.44.4.792. View

13.

Spyer K . Neural organisation and control of the baroreceptor reflex. Rev Physiol Biochem Pharmacol. 1981; 88:24-124. View

14.

Potter E . Inspiratory inhibition of vagal responses to baroreceptor and chemoreceptor stimuli in the dog. J Physiol. 1981; 316:177-90. PMC: 1248143. DOI: 10.1113/jphysiol.1981.sp013781. View

15.

Donoghue S, Garcia M, Jordan D, Spyer K . Identification and brain-stem projections of aortic baroreceptor afferent neurones in nodose ganglia of cats and rabbits. J Physiol. 1982; 322:337-52. PMC: 1249673. DOI: 10.1113/jphysiol.1982.sp014040. View

16.

Donoghue S, Garcia M, Jordan D, Spyer K . The brain-stem projections of pulmonary stretch afferent neurones in cats and rabbits. J Physiol. 1982; 322:353-63. PMC: 1249674. DOI: 10.1113/jphysiol.1982.sp014041. View

17.

Czachurski J, Lackner K, Ockert D, SELLER H . Localization of neurones with baroreceptor input in the medial solitary nucleus by means of intracellular application of horseradish peroxidase in the cat. Neurosci Lett. 1982; 28(2):133-7. DOI: 10.1016/0304-3940(82)90141-0. View

18.

Spyer K . Central nervous integration of cardiovascular control. J Exp Biol. 1982; 100:109-28. DOI: 10.1242/jeb.100.1.109. View

19.

Donoghue S, Felder R, Jordan D, Spyer K . The central projections of carotid baroreceptors and chemoreceptors in the cat: a neurophysiological study. J Physiol. 1984; 347:397-409. PMC: 1199453. DOI: 10.1113/jphysiol.1984.sp015072. View

20.

Gilbey M, Jordan D, Richter D, Spyer K . Synaptic mechanisms involved in the inspiratory modulation of vagal cardio-inhibitory neurones in the cat. J Physiol. 1984; 356:65-78. PMC: 1193152. DOI: 10.1113/jphysiol.1984.sp015453. View