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Rutoside and Ascorbic Acid in the Treatment of Schamberg Pigmented Purpuric Dermatosis

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Journal Cureus
Date 2021 May 26
PMID 34036010
Citations 3
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Abstract

Schamberg disease is a type of pigmented purpuric dermatosis (PPD), which is a benign cutaneous capillaritis characterized by macules and patches most commonly found on the lower extremities. Rutoside and ascorbic acid have been shown in previous cases to be efficacious in the treatment of PPD lesions due to their free radical scavenging effect on capillaries. We present the case of a 19-year-old woman with Schamberg disease who achieved complete clearance of lesions within four months of daily rutoside and ascorbic acid treatment. The goal of this case report is to further demonstrate the effectiveness of this treatment and to call for investigation of its use as a standard of care in PPD.

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References
1.
Halliwell B . The role of oxygen radicals in human disease, with particular reference to the vascular system. Haemostasis. 1993; 23 Suppl 1:118-26. DOI: 10.1159/000216921. View

2.
Robak J, Gryglewski R . Flavonoids are scavengers of superoxide anions. Biochem Pharmacol. 1988; 37(5):837-41. DOI: 10.1016/0006-2952(88)90169-4. View

3.
RANDALL S, KIERLAND R, Montgomery H . Pigmented purpuric eruptions. AMA Arch Derm Syphilol. 1951; 64(2):177-91. DOI: 10.1001/archderm.1951.01570080061009. View

4.
Frei B . Reactive oxygen species and antioxidant vitamins: mechanisms of action. Am J Med. 1994; 97(3A):5S-13S; discussion 22S-28S. DOI: 10.1016/0002-9343(94)90292-5. View

5.
Taniyama Y, Griendling K . Reactive oxygen species in the vasculature: molecular and cellular mechanisms. Hypertension. 2003; 42(6):1075-81. DOI: 10.1161/01.HYP.0000100443.09293.4F. View