RPLP1 is Highly Expressed in Hepatocellular Carcinoma Tissues and Promotes Proliferation, Invasion and Migration of Human Hepatocellular Carcinoma Hep3b Cells

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2021 May 26

PMID 34035849

Citations 10

Authors

Changji Xie

Kai Cao

Dexin Peng

Lei Qin

Affiliations

Soon will be listed here.

Abstract

Hepatocellular carcinoma (HCC) is a common primary malignant tumor with a high mortality rate. Increasing evidence suggests that ribosomal protein LP1 (RPLP1) is involved in the progression of different types of cancer. Thus, the present study aimed to investigate the underlying molecular mechanism of RPLP1 in HCC progression. The cellular behaviors of Hep3b cells were assessed via Cell Counting Kit-8, colony formation, wound healing and Transwell assays. Western blot analysis was performed to detect protein expression levels, while reverse transcription-quantitative PCR analysis was performed to detect mRNA expression levels. The results demonstrated that RPLP1 was highly expressed in HCC tissues and cells, and the overexpression of RPLP1 was associated with a less favorable prognosis of patients with HCC. Notably, downregulation of RPLP1 significantly suppressed the proliferation, migration and invasion of Hep3b cells. Taken together, the results of the present study suggested that RPLP1 acts as an oncogene in HCC, and thus may be used to treat patients with HCC.

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