Using Dynamic Cell Communication Improves Treatment Strategies of Breast Cancer

Overview

Journal Cancer Cell Int

Publisher Biomed Central

Date 2021 May 26

PMID 34034721

Citations 2

Authors

Zhibo Liu

Song Hu

Zehui Yun

Wanshan Hu

Shuhua Zhang

Daya Luo

Affiliations

Soon will be listed here.

Abstract

Several insights from the clinical treatment of breast cancer patients have revealed that only a portion of patients achieve the expected curative effect after traditional targeted therapy, that surgical treatment may promote the development of cancer metastasis, and that the optimal combination of neoadjuvant chemotherapy and traditional treatment is not clear. Therefore, a more precise classification of breast cancer and selection of treatment methods should be undertaken to improve the efficacy of clinical treatment. In the clinical treatment of breast cancer, cell communication molecules are often selected as therapeutic targets. However, various cell communications are not static. Their dynamic changes are related to communicating cells, communicating molecules, and various intertwined internal and external environmental factors. Understanding the dynamic microenvironment can help us improve therapeutic efficacy and provide new ways to more accurately determine the cancer status. Therefore, this review describes multiple types of cellular communication in the breast cancer microenvironment and incorporates internal and external environmental factors as variable signaling factors in cell communication. Using dynamic and developmental concepts, we summarize the functional changes in signaling molecules and cells to aid in the diagnosis and treatment of breast cancer.

Citing Articles

Cell signaling pathways discovery from multi-modal data.

He C, Simpson C, Cossentino I, Zhang B, Tkachev S, Eddins D bioRxiv. 2025; .

PMID: 39975141 PMC: 11839107. DOI: 10.1101/2025.02.06.636961.

Nanoparticle-Based Antioxidants in Stress Signaling and Programmed Cell Death in Breast Cancer Treatment.

Herdiana Y, Sriwidodo S, Sofian F, Wilar G, Diantini A Molecules. 2023; 28(14).

PMID: 37513179 PMC: 10384004. DOI: 10.3390/molecules28145305.

Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications.

Naskar A, Cho H, Lee S, Kim K Pharmaceutics. 2021; 13(11).

PMID: 34834302 PMC: 8618801. DOI: 10.3390/pharmaceutics13111887.

References

Orimo A, Gupta P, Sgroi D, Arenzana-Seisdedos F, Delaunay T, Naeem R . Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell. 2005; 121(3):335-48. DOI: 10.1016/j.cell.2005.02.034. View

Li J, Qi D, Hsieh T, Huang J, Wu J, Wu E . Trailblazing perspectives on targeting breast cancer stem cells. Pharmacol Ther. 2021; 223:107800. DOI: 10.1016/j.pharmthera.2021.107800. View

Higginbotham J, Demory Beckler M, Gephart J, Franklin J, Bogatcheva G, Kremers G . Amphiregulin exosomes increase cancer cell invasion. Curr Biol. 2011; 21(9):779-86. PMC: 3417320. DOI: 10.1016/j.cub.2011.03.043. View

Galmarini C, Tredan O, Galmarini F . Concomitant resistance and early-breast cancer: should we change treatment strategies?. Cancer Metastasis Rev. 2013; 33(1):271-83. DOI: 10.1007/s10555-013-9449-1. View

Hamidullah , Changkija B, Konwar R . Role of interleukin-10 in breast cancer. Breast Cancer Res Treat. 2011; 133(1):11-21. DOI: 10.1007/s10549-011-1855-x. View

Garcia-Quiroz J, Rivas-Suarez M, Garcia-Becerra R, Barrera D, Martinez-Reza I, Ordaz-Rosado D . Calcitriol reduces thrombospondin-1 and increases vascular endothelial growth factor in breast cancer cells: implications for tumor angiogenesis. J Steroid Biochem Mol Biol. 2013; 144 Pt A:215-22. DOI: 10.1016/j.jsbmb.2013.09.019. View

Hollmen M, Roudnicky F, Karaman S, Detmar M . Characterization of macrophage--cancer cell crosstalk in estrogen receptor positive and triple-negative breast cancer. Sci Rep. 2015; 5:9188. PMC: 4361875. DOI: 10.1038/srep09188. View

Ali S, Coombes R . Endocrine-responsive breast cancer and strategies for combating resistance. Nat Rev Cancer. 2003; 2(2):101-12. DOI: 10.1038/nrc721. View

Zhang B, Whiteaker J, Hoofnagle A, Baird G, Rodland K, Paulovich A . Clinical potential of mass spectrometry-based proteogenomics. Nat Rev Clin Oncol. 2018; 16(4):256-268. PMC: 6448780. DOI: 10.1038/s41571-018-0135-7. View

10.

Mundhenke C, Meyer K, Drew S, Friedl A . Heparan sulfate proteoglycans as regulators of fibroblast growth factor-2 receptor binding in breast carcinomas. Am J Pathol. 2002; 160(1):185-94. PMC: 1867116. DOI: 10.1016/S0002-9440(10)64362-3. View

11.

Brucher B, Jamall I . Cell-cell communication in the tumor microenvironment, carcinogenesis, and anticancer treatment. Cell Physiol Biochem. 2014; 34(2):213-43. DOI: 10.1159/000362978. View

12.

Holen I, Whitworth J, Nutter F, Evans A, Brown H, Lefley D . Loss of plakoglobin promotes decreased cell-cell contact, increased invasion, and breast cancer cell dissemination in vivo. Breast Cancer Res. 2012; 14(3):R86. PMC: 3446349. DOI: 10.1186/bcr3201. View

13.

Kwa M, Plottel C, Blaser M, Adams S . The Intestinal Microbiome and Estrogen Receptor-Positive Female Breast Cancer. J Natl Cancer Inst. 2016; 108(8). PMC: 5017946. DOI: 10.1093/jnci/djw029. View

14.

Thery C, Zitvogel L, Amigorena S . Exosomes: composition, biogenesis and function. Nat Rev Immunol. 2002; 2(8):569-79. DOI: 10.1038/nri855. View

15.

Chen Q, Fang X, Jiang C, Yao N, Fang X . Thrombospondin promoted anti-tumor of adenovirus-mediated calreticulin in breast cancer: Relationship with anti-CD47. Biomed Pharmacother. 2015; 73:109-15. DOI: 10.1016/j.biopha.2015.05.017. View

16.

Mallepell S, Krust A, Chambon P, Brisken C . Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland. Proc Natl Acad Sci U S A. 2006; 103(7):2196-201. PMC: 1413744. DOI: 10.1073/pnas.0510974103. View

17.

Gao S, Ge A, Xu S, You Z, Ning S, Zhao Y . PSAT1 is regulated by ATF4 and enhances cell proliferation via the GSK3β/β-catenin/cyclin D1 signaling pathway in ER-negative breast cancer. J Exp Clin Cancer Res. 2017; 36(1):179. PMC: 5721480. DOI: 10.1186/s13046-017-0648-4. View

18.

Acerbi I, Cassereau L, Dean I, Shi Q, Au A, Park C . Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration. Integr Biol (Camb). 2015; 7(10):1120-34. PMC: 4593730. DOI: 10.1039/c5ib00040h. View

19.

Harris J, Dave K, Gorman J, Khanna K . The breast cancer antigen 5T4 interacts with Rab11, and is a target and regulator of Rab11 mediated trafficking. Int J Biochem Cell Biol. 2018; 99:28-37. DOI: 10.1016/j.biocel.2018.03.002. View

20.

Jang J, Lee J, Jeon Y, Kim C . Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization. BMC Cancer. 2013; 13:421. PMC: 3848851. DOI: 10.1186/1471-2407-13-421. View