A Risk Score Based on Procalcitonin for Predicting Acute Kidney Injury in COVID-19 Patients

Overview

Journal J Clin Lab Anal

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
Pathology

Date 2021 May 25

PMID 34032326

Citations 9

Authors

Ruo Ran Wang

Min He

Yan Kang

Affiliations

Soon will be listed here.

Abstract

Background: Acute kidney injury (AKI) has been reported developing commonly in coronavirus disease 2019 (COVID-19) patients and could increase the risk of poor outcomes in these patients. We design this study to explore the value of serum procalcitonin (PCT) on predicting AKI and construct risk score for predicting AKI in COVID-19 patients.

Methods: Patients diagnosed with COVID-19 and hospitalized in Renmin Hospital of Wuhan University between January 30 and February 24, 2020, were included. The least absolute shrinkage and selection operator (LASSO) regression was performed to identify the strongest predictors of AKI. Multivariate logistic regression analysis was conducted to find independent risk factors for AKI and construct risk score using odds ratio (OR) value of those risk factors. Receiver operating characteristics (ROC) curves were plotted, and area under the ROC curve (AUC) value was calculated to evaluate the predictive value of single PCT level and the constructed risk score.

Results: Among 389 included COVID-19 patients, 28 (7.2%) patients developed AKI. LASSO regression showed hypertension, saturation of arterial oxygen (SaO ), PCT, and blood urea nitrogen (BUN) were the strongest predictors for AKI. After multivariate logistic regression analysis, only SaO (<0.001), PCT (p = 0.004), and BUN (p = 0.005) were independently associated with development of AKI in COVID-19 patients. The AUC of single PCT and constructed risk score was 0. 881 and 0.928, respectively.

Conclusion: PCT level is correlated with AKI in COVID-19 patients. The efficient risk score consisted of SaO , PCT, and BUN is readily accessible for physicians to evaluate the possibility of AKI in COVID-19 patients.

Citing Articles

Our Experience with SARS-CoV-2 Infection and Acute Kidney Injury: Results from a Single-Center Retrospective Observational Study.

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Serum procalcitonin level is independently associated with mechanical ventilation and case-fatality in hospitalized COVID-19-positive US veterans-A potential marker for disease severity.

Jeyapalina S, Wei G, Stoddard G, Sudduth J, Lundquist M, Huntsman M PLoS One. 2023; 18(4):e0284520.

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Development of a Risk Score for AKI onset in COVID-19 Patients: COV-AKI Score.

Palomba H, Cubos D, Bozza F, Zampieri F, Romano T BMC Nephrol. 2023; 24(1):46.

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Outcomes, Healthcare Resource Utilization, and Costs of Overall, Community-Acquired, and Hospital-Acquired Acute Kidney Injury in COVID-19 Patients.

Koyner J, Mackey R, Rosenthal N, Carabuena L, Kampf J, McPherson P J Health Econ Outcomes Res. 2023; 10(1):31-40.

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The Association between Admission Procalcitonin Level and The Severity of COVID-19 Pneumonia: A Retrospective Cohort Study.

Aon M, Alsaeedi A, Alzafiri A, Ibrahim M, Al-Shammari A, Al-Shammari O Medicina (Kaunas). 2022; 58(10).

PMID: 36295550 PMC: 9611309. DOI: 10.3390/medicina58101389.

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