A Prospective Study of the Relation Between Smoking and Fertility

Overview

Journal Int J Epidemiol

Specialty Public Health

Date 1988 Jun 1

PMID 3403134

Citations 18

Authors

J de Mouzon

A Spira

D Schwartz

Affiliations

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Abstract

A prospective study of fertility was conducted from 1977 to 1982. Analysis of the relation between cigarette smoking and occurrence of a pregnancy was performed on 1887 couples. The actuarial pregnancy rate was 82.9% at the end of a year. Cigarette smoking by both members of the couple was found to be related to decreased fertility when this factor was considered alone. But after including all the confounding covariates in a Cox semi-proportional hazards model for survival data, no relationship remained between cigarette smoking and fertility. Odds ratios were respectively 0.86 (95% confidence interval: 0.63, 1.19) and 0.99 (0.85, 1.14) for women smoking and men smoking. This could suggest that the relationship found by other authors might be at least partly explained by a relation between cigarette smoking and other factors related to fertility.

Citing Articles

Smoking and infertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study.

Hernaez A, Wootton R, Page C, Skara K, Fraser A, Rogne T Fertil Steril. 2022; 118(1):180-190.

PMID: 35562204 PMC: 7612999. DOI: 10.1016/j.fertnstert.2022.04.001.

Fertility of Women Treated during Childhood with Triptorelin (Depot Formulation) for Central Precocious Puberty: The PREFER Study.

Martinerie L, de Mouzon J, Blumberg J, di Nicola L, Maisonobe P, Carel J Horm Res Paediatr. 2021; 93(9-10):529-538.

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Smoke, alcohol and drug addiction and female fertility.

de Angelis C, Nardone A, Garifalos F, Pivonello C, Sansone A, Conforti A Reprod Biol Endocrinol. 2020; 18(1):21.

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Prospective study of cigarette smoking and fecundability.

Wesselink A, Hatch E, Rothman K, Mikkelsen E, Aschengrau A, Wise L Hum Reprod. 2018; 34(3):558-567.

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The Home Observation of Periconceptional Exposures (HOPE) study, a prospective cohort: aims, design, recruitment and compliance.

Porucznik C, Cox K, Schliep K, Wilkins D, Stanford J Environ Health. 2016; 15(1):67.

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