Are the Clinical Manifestations of CT Scan and Location Associated with World Health Organization Histopathological Grades of Meningioma?: A Retrospective Study

Overview

Journal Ann Med Surg (Lond)

Publisher Wolters Kluwer

Specialty Medical Education

Date 2021 May 24

PMID 34026110

Citations 1

Authors

Razieh Behzadmehr

Rezvaneh Behzadmehr

Affiliations

Soon will be listed here.

Abstract

Introduction: meningioma is the most common intracranial tumor. CT scan is a common method for diagnosis. WHO classified meningioma into 3 histological grades? This study aims to evaluate the relation of different meningioma signs on CT and tumor distribution regard to WHO histological types.

Methods: In this single-center observational retrospective study, authors reviewed data of 75 meningioma patients confirmed by the WHO histological grades (WHO I/II/III) which were underwent CT scans from January 1, 2005 to December 30, 2019 at a teaching hospital, in XXXX. Data collected using patients medical records. Data were analyzed by SPSS 20 and P less than 0.05 was assumed as significant.

Result: Our study confirmed that only edema (P = 0.005) and heterogeneity (P = 0.014) had a significant association with malignant histological types. Other signs were not statistically different among WHO histology types (p > 0.05). On the subject of tumor location, atypical/malignant meningioma was significantly more common in parasagittal (P = 0.031) and front-parietal (P = 0.035) regions.

Discussion: meningiomas with Edema, heterogeneity on CT, and tumors located in parasagittal and frontoparietal regions are related to malignant histology and should be evaluated and treated more precisely.

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References

Xiaoai K, Qing Z, Lei H, Junlin Z . Differentiating microcystic meningioma from atypical meningioma using diffusion-weighted imaging. Neuroradiology. 2020; 62(5):601-607. DOI: 10.1007/s00234-020-02374-3. View

Gurkanlar D, Er U, Sanli M, Ozkan M, Sekerci Z . Peritumoral brain edema in intracranial meningiomas. J Clin Neurosci. 2005; 12(7):750-3. DOI: 10.1016/j.jocn.2004.09.029. View

Marosi C, Hassler M, Roessler K, Reni M, Sant M, Mazza E . Meningioma. Crit Rev Oncol Hematol. 2008; 67(2):153-71. DOI: 10.1016/j.critrevonc.2008.01.010. View

Haeren R, Rautalin I, Schwartz C, Korja M, Niemela M . Surgery on giant meningiomas in very old patients entails frequent postoperative intracranial hemorrhages and atypical histopathology. J Neurooncol. 2021; 152(1):195-204. PMC: 7910228. DOI: 10.1007/s11060-020-03693-4. View

Walsh K . Epidemiology of meningiomas. Handb Clin Neurol. 2020; 169:3-15. DOI: 10.1016/B978-0-12-804280-9.00001-9. View

Baek J, Cho Y, Yoo J . An osteolytic meningioma en plaque of the sphenoid ridge. J Korean Neurosurg Soc. 2008; 43(1):34-6. PMC: 2588156. DOI: 10.3340/jkns.2008.43.1.34. View

Rockhill J, Mrugala M, Chamberlain M . Intracranial meningiomas: an overview of diagnosis and treatment. Neurosurg Focus. 2007; 23(4):E1. DOI: 10.3171/FOC-07/10/E1. View

Ressel A, Fichte S, Brodhun M, Rosahl S, Gerlach R . WHO grade of intracranial meningiomas differs with respect to patient's age, location, tumor size and peritumoral edema. J Neurooncol. 2019; 145(2):277-286. DOI: 10.1007/s11060-019-03293-x. View

Schwartz C, Rautalin I, Niemela M, Korja M . Symptomatic peritumoral edema is associated with surgical outcome: a consecutive series of 72 supratentorial meningioma patients ≥ 80 years of age. J Neurooncol. 2020; 148(1):109-116. DOI: 10.1007/s11060-020-03501-z. View

10.

Spille D, Adeli A, Sporns P, Hess K, Streckert E, Brokinkel C . Predicting the risk of postoperative recurrence and high-grade histology in patients with intracranial meningiomas using routine preoperative MRI. Neurosurg Rev. 2020; 44(2):1109-1117. PMC: 8450214. DOI: 10.1007/s10143-020-01301-7. View

11.

Hu S, Li F, Hu R, Cui G, Meng H, Feng H . Atypical histopathologic type of cystic meningioma. Acta Neurochir (Wien). 2009; 152(1):105-9. DOI: 10.1007/s00701-009-0426-y. View

12.

Novak Z, Chrastina J, Lzicarova E, riha I . [Meningiomas with skull bone involvement]. Rozhl Chir. 2006; 85(6):255-9. View

13.

Martinez-Perez R, Hardesty D, Palmer J, Zachariah M, Otto B, Carrau R . Remote Leptomeningeal Dissemination in Olfactory Neuroblastoma Mimicking Multiple Parasagittal Meningiomas: Diagnostic and Therapeutic Challenge. World Neurosurg. 2019; 134:361-364. DOI: 10.1016/j.wneu.2019.11.042. View

14.

Zhang J, Sun J, Han T, Zhao Z, Cao Y, Zhang G . Radiomic features of magnetic resonance images as novel preoperative predictive factors of bone invasion in meningiomas. Eur J Radiol. 2020; 132:109287. DOI: 10.1016/j.ejrad.2020.109287. View

15.

Sapkota M, Yang Z, Zhu D, Zhang Y, Yuan T, Gao J . Evaluation of Epidemiologic Factors, Radiographic Features, and Pathologic Findings for Predicting Peritumoral Brain Edema in Meningiomas. J Magn Reson Imaging. 2020; 52(1):174-182. DOI: 10.1002/jmri.27046. View

16.

Ramos-Fresnedo A, Domingo R, Vivas-Buitrago T, Lundy L, Trifiletti D, Jentoft M . Multiple meningiomas: does quantity matter? a population-based survival analysis with underlined age and sex differences. J Neurooncol. 2020; 149(3):413-420. DOI: 10.1007/s11060-020-03620-7. View

17.

Omofoye O, Huynh T, Jhun R, Ashfaque H, Cronk K . Primary intraosseous meningioma of the calvarium: A systematic review. Clin Neurol Neurosurg. 2020; 199:106283. DOI: 10.1016/j.clineuro.2020.106283. View

18.

Ostrom Q, Patil N, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan J . CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2013-2017. Neuro Oncol. 2020; 22(12 Suppl 2):iv1-iv96. PMC: 7596247. DOI: 10.1093/neuonc/noaa200. View

19.

Hsu C, Pai C, Kao H, Hsueh C, Hsu W, Lo C . Do aggressive imaging features correlate with advanced histopathological grade in meningiomas?. J Clin Neurosci. 2010; 17(5):584-7. DOI: 10.1016/j.jocn.2009.09.018. View

20.

Hale A, Wang L, Strother M, Chambless L . Differentiating meningioma grade by imaging features on magnetic resonance imaging. J Clin Neurosci. 2017; 48:71-75. DOI: 10.1016/j.jocn.2017.11.013. View