Pneumococcal Bacteremia in Cancer Patients

Overview

Journal Eur J Epidemiol

Specialty Public Health

Date 1988 Jun 1

PMID 3402582

Citations 1

Authors

V Richard

F Meunier

P Van der Auwera

P Dejace

D Daneau

J Klastersky

Affiliations

Soon will be listed here.

Abstract

Twenty-eight episodes of Streptococcus pneumoniae bacteremia occurring in 27 cancer patients hospitalized in the Institut Jules Bordet between July 1979 and April 1985 were reviewed. Ten patients had hematological malignancies and 17 had solid tumors (in 7 cases, of the lung). Forty-four per cent of the patients were neutropenic (less than 1000/microliters) and 36% of the patients were in septic shock. In 36% of the patients no clinical source of S. pneumoniae bacteremia could be found. Seventy-nine (21% patients) received empirical antibiotic treatment containing a beta-lactam. Two patients who did not receive any empirical treatment died within 12 hours. Overall, 11/27 patients died within the first week, and 8/27 died within the first three days. Mortality in neutropenic patients was not different from that in non-neutropenic patients. In comparison with a similar study performed previously in our institution, there was no difference in incidence, type of patient, source of bacteremia, or mortality.

Citing Articles

Fluoroquinolone treatment as a protective factor for 10-day mortality in Streptococcus pneumoniae bacteremia in cancer patients.

Fontana N, Ibrahim K, Bonazzi P, Rossi F, Almeida S, Tengan F Sci Rep. 2021; 11(1):3699.

PMID: 33580101 PMC: 7881156. DOI: 10.1038/s41598-021-81415-0.

References

. Update: pneumococcal polysaccharide vaccine usage--United States. Recommendations of the Immunization Practices Advisory Committee. Ann Intern Med. 1984; 101(3):348-50. View

Woodhead M, Macfarlane J, Rodgers F, Laverick A, Pilkington R, MACRAE A . Aetiology and outcome of severe community-acquired pneumonia. J Infect. 1985; 10(3):204-10. DOI: 10.1016/s0163-4453(85)92463-6. View

Wade J, Schimpff S, Newman K, Wiernik P . Staphylococcus epidermidis: an increasing cause of infection in patients with granulocytopenia. Ann Intern Med. 1982; 97(4):503-8. DOI: 10.7326/0003-4819-97-4-503. View

Zarrabi M, Rosner F . Rarity of failure of penicillin prophylaxis to prevent postsplenectomy sepsis. Arch Intern Med. 1986; 146(6):1207-8. View

Austrian R . Some observations on the pneumococcus and on the current status of pneumococcal disease and its prevention. Rev Infect Dis. 1981; 3 Suppl:S1-17. DOI: 10.1093/clinids/3.supplement_1.s1. View

Pizzo P, Ladisch S, Simon R, Gill F, Levine A . Increasing incidence of Gram-positive sepsis in cancer patients. Med Pediatr Oncol. 1978; 5(1):241-4. DOI: 10.1002/mpo.2950050133. View

Austrian R, Gold J . PNEUMOCOCCAL BACTEREMIA WITH ESPECIAL REFERENCE TO BACTEREMIC PNEUMOCOCCAL PNEUMONIA. Ann Intern Med. 1964; 60:759-76. DOI: 10.7326/0003-4819-60-5-759. View

Chou M, Brown A, BLEVINS A, Armstrong D . Severe pneumococcal infection in patients with neoplastic disease. Cancer. 1983; 51(8):1546-50. DOI: 10.1002/1097-0142(19830415)51:8<1546::aid-cncr2820510832>3.0.co;2-a. View

Winston D, Dudnick D, CHAPIN M, Ho W, Gale R, Martin W . Coagulase-negative staphylococcal bacteremia in patients receiving immunosuppressive therapy. Arch Intern Med. 1983; 143(1):32-6. View

10.

Klastersky J, Mommen P, Cantraine F, Safary A . Placebo controlled pneumococcal immunization in patients with bronchogenic carcinoma. Eur J Cancer Clin Oncol. 1986; 22(7):807-13. DOI: 10.1016/0277-5379(86)90367-6. View

11.

Folland D, Armstrong D, Seides S, BLEVINS A . Pneumococcal bacteremia in patients with neoplastic disease. Cancer. 1974; 33(3):845-9. DOI: 10.1002/1097-0142(197403)33:3<845::aid-cncr2820330333>3.0.co;2-6. View

12.

Bartlett J, OKeefe P, Tally F, Louie T, Gorbach S . Bacteriology of hospital-acquired pneumonia. Arch Intern Med. 1986; 146(5):868-71. View

13.

Bernard C, Mombelli G, Klastersky J . Pneumococcal bacteremia in patients with neoplastic diseases. Eur J Cancer Clin Oncol. 1981; 17(9):1041-6. DOI: 10.1016/s0277-5379(81)80011-9. View

14.

Winston D, Schiffman G, Wang D, Feig S, Lin C, Marso E . Pneumococcal infections after human bone-marrow transplantation. Ann Intern Med. 1979; 91(6):835-41. DOI: 10.7326/0003-4819-91-6-835. View

15.

Bolan G, Broome C, Facklam R, Plikaytis B, Fraser D, Schlech 3rd W . Pneumococcal vaccine efficacy in selected populations in the United States. Ann Intern Med. 1986; 104(1):1-6. DOI: 10.7326/0003-4819-104-1-1. View

16.

Wara D . Host defense against Streptococcus pneumoniae: the role of the spleen. Rev Infect Dis. 1981; 3(2):299-309. DOI: 10.1093/clinids/3.2.299. View

17.

Shapiro E, Clemens J . A controlled evaluation of the protective efficacy of pneumococcal vaccine for patients at high risk of serious pneumococcal infections. Ann Intern Med. 1984; 101(3):325-30. DOI: 10.7326/0003-4819-101-3-325. View

18.

Klastersky J, Glauser M, Schimpff S, Zinner S, Gaya H . Prospective randomized comparison of three antibiotic regimens for empirical therapy of suspected bacteremic infection in febrile granulocytopenic patients. Antimicrob Agents Chemother. 1986; 29(2):263-70. PMC: 176388. DOI: 10.1128/AAC.29.2.263. View

19.

Alvarez S, Guarderas J, Shell C, Berk S . Nosocomial pneumococcal bacteremia. Arch Intern Med. 1986; 146(8):1509-12. View

20.

Landesman S, Schiffman G . Assessment of the antibody response to pneumococcal vaccine in high-risk populations. Rev Infect Dis. 1981; 3 Suppl:S184-97. DOI: 10.1093/clinids/3.supplement_1.s184. View