WNT5B in Physiology and Disease

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2021 May 21

PMID 34017835

Citations 25

Authors

Sarocha Suthon

Rachel S Perkins

Vitezslav Bryja

Gustavo A Miranda-Carboni

Susan A Krum

Affiliations

Soon will be listed here.

Abstract

WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B signals through the non-canonical β-catenin-independent signaling pathway and often functions as an antagonist of canonical WNT signaling. Although WNT5B has a high amino acid identity with WNT5A and is often assumed to have similar activities, WNT5B often exhibits unique expression patterns and functions. Here, we describe the distinct effects and mechanisms of WNT5B on development, bone, adipose tissue, cardiac tissue, the nervous system, the mammary gland, the lung and hematopoietic cells, compared to WNT5A. We also highlight aberrances in non-canonical WNT5B signaling contributing to diseases such as osteoarthritis, osteoporosis, obesity, type 2 diabetes mellitus, neuropathology, and chronic diseases associated with aging, as well as various cancers.

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