Hyaluronic Acid Reduces Fibrosis in a Rabbit Model of Urethral Anastomosis

Overview

Journal Res Rep Urol

Publisher Dove Medical Press

Specialty Urology

Date 2021 May 21

PMID 34017802

Authors

Eliseo Portilla-de Buen

Juan Pablo Ramirez-Contreras

Jonathan Matias Chejfec-Ciociano

Rodrigo Lopez-Falcony

David Garcia-Martinez

Jose Gonzalo Vazquez-Camacho

Clotilde Fuentes-Orozco

Francisco Jose Barbosa-Camacho

Juan Carlos Ibarrola-Pena

Alejandro Gonzalez-Ojeda

Affiliations

Soon will be listed here.

Abstract

Introduction: Urethral stricture caused by fibrosis is a common medical condition, but top-line therapy for this pathology has a high recurrence rate. This study aimed to determine the efficacy of hyaluronic acid (HA) treatment in preventing the development of fibrosis in a rabbit model of urethral anastomosis.

Materials And Methods: This experimental study involved 20 rabbits. HA (0.5 mL, 25 μg/mL) was applied in the experimental group (n = 10) during an experimental urethral anastomosis, and sterile saline (0.9%) solution was applied in the control group (n = 10). Animals underwent reoperation 12 weeks later for urethral resection. Fibrosis, inflammation, and urethral diameter were measured by two blinded pathologists at the site of the anastomosis.

Results: The amount of inflammatory infiltrate was similar in both groups. The thicknesses of the collagen fiber band were 275.9 ± 62.3 and 373.4 ± 44.3 μm in the study and control groups (p = 0.001), respectively, and the urethral lumen diameters at the anastomosis site at follow-up were 2575 ± 167 and 2382 ± 214 μm, respectively (p = 0.04).

Conclusion: HA treatment reduced fibrosis at the anastomosis site during this experiment; we suggest further research to corroborate its efficacy in the treatment of urethral stricture.

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