The Quality of Life of Patients with Pacemaker-induced Cardiomyopathy After They Upgrade to Left Bundle Branch Pacing

Overview

Journal Am J Transl Res

Specialty General Medicine

Date 2021 May 21

PMID 34017472

Citations 6

Authors

Huacheng Li

Long Wang

Xinna Peng

Jiying Wu

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the changes in the cardiac function and quality of life of patients with pacemaker-induced cardiomyopathy (PICM) after they upgrade to left bundle branch pacing (LBBP).

Methods: Ten patients with PICM who upgraded to LBBP were recruited as the study cohort. The LBBP upgrade operations were all performed by the same cardiac intervention expert. The cardiac function index changes, including the left ventricular end-diastolic diameters, the cardiothoracic ratios, the left ventricular ejection fractions, the N-terminal brain natriuretic peptide levels, the 6 min walking test distances, and the quality of life changes, including the SF-36 scores, the European Five-Dimensional Health Scale (EQ-5D-3L) scores, and the Minnesota Heart failure Quality of Life Scale (MLHFQ) scores before and after the LBBP operations were analyzed. The incidences of adverse events during the postoperative follow-up were analyzed.

Results: The ten patients were successfully upgraded to LBBP. Compared with before the operation, the left ventricular end-diastolic diameter levels and the cardiothoracic ratios decreased significantly, but the left ventricular ejection fractions and the 6 min walking test distances increased (P<0.05 or P<0.01). The SF-36 and EQ-5D-3L scores increased gradually, but the MLHFQ scores decreased gradually before the operations and at one month and 12 months after the operations. The physical functioning (PF), role-physical (RP), general health (GH), vitality (VT), and the social role (SR) scores of the SF-36 scale, the TTO index and the visual analog scale (VAS) of the EQ-5D-3L scale scores, and the MLHFQ scores at 12 months after the operations were significantly different from the scores before the operations (all P<0.05). In terms of safety, there were no adverse events such as pacemaker electrode dislocation or interventricular septal perforation during the postoperative follow-up.

Conclusion: Upgrading to LBBP can effectively improve cardiac function and the quality of life in patients with PICM, and the operation is safe.

Citing Articles

Effectiveness of upgrade left bundle branch area pacing for right ventricular pacing-induced cardiomyopathy: Extra QRS shortening matters.

Huang H, Li X, Long T, Yu Y, Cheng S, Ning X J Arrhythm. 2025; 41(1):e70017.

PMID: 39950145 PMC: 11822657. DOI: 10.1002/joa3.70017.

Comparative analysis of left bundle branch area pacing in patients with and without a history of open-heart surgery.

Nohno Y, Kozu R, Ito K, Chikazawa Y, Maruyama S, Hasegawa T J Arrhythm. 2025; 41(1):e70010.

PMID: 39886037 PMC: 11780717. DOI: 10.1002/joa3.70010.

Pacemaker-induced Cardiomyopathy in Patients with Coronary Artery Disease: A Report of Three Cases.

Gul E, Ghazni M, Gamal G J Innov Card Rhythm Manag. 2024; 15(1):5735-5738.

PMID: 38304093 PMC: 10829413. DOI: 10.19102/icrm.2024.15011.

Beneficial effects of upgrading to His-Purkinje system pacing in patients with pacing-induced cardiomyopathy: a systematic review and meta-analysis.

Tang N, Chen X, Li H, Zhang D PeerJ. 2023; 11:e16268.

PMID: 37842060 PMC: 10576494. DOI: 10.7717/peerj.16268.

Recruitment of the cardiac conduction system for optimal resynchronization therapy in failing heart.

Chen Z, Zhou X, Ma X, Chen K Front Physiol. 2023; 13:1045740.

PMID: 36589433 PMC: 9798297. DOI: 10.3389/fphys.2022.1045740.

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