Mucormycosis

Overview

Journal Infect Dis Clin North Am

Specialty Infectious Diseases

Date 2021 May 21

PMID 34016285

Citations 42

Authors

Julie M Steinbrink

Marisa H Miceli

Affiliations

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Abstract

Mucormycosis is a rare but aggressive fungal disease that mainly affects patients with poorly controlled diabetes mellitus and those who are severely immunocompromised, including patients with hematological malignancies and solid organ transplant recipients. Early recognition of infection is critical for treatment success, followed by prompt initiation of antifungal therapy with lipid formulation amphotericin B. Posaconazole and isavuconazole should be used for stepdown and salvage therapy. Surgical debridement is key for tissue diagnosis and treatment and should be pursued urgently whenever possible. In addition to surgery and antifungal therapy, reverting the underlying risk factor for infection is important for treatment response.

Citing Articles

Acute Necrotizing Fasciitis Caused by Infection in a Patient with Diabetes and Pulmonary Tuberculosis: A Case Report.

Huang X, Qiu J, Pan L, Wang C, Tang C Infect Drug Resist. 2025; 18:775-782.

PMID: 39958980 PMC: 11827498. DOI: 10.2147/IDR.S503791.

Real-World Effectiveness and Safety of Isavuconazole Versus Amphotericin B for Patients with Invasive Mucormycosis.

Qin J, Bi H, Tang G, Liu X, Qu J, Lv X Microorganisms. 2025; 13(1).

PMID: 39858823 PMC: 11767576. DOI: 10.3390/microorganisms13010055.

A case of mucormycosis caused by Rhizopus microsporus in a renal transplant patient.

Fukuda M, Yokoyama T, Marie M, Miki K, Yamanouchi M, Mizuno H CEN Case Rep. 2025; .

PMID: 39832047 DOI: 10.1007/s13730-025-00969-4.

Pulmonary mucormycosis in an immunocompetent young female: a case report and literature review.

Zhang X, Wu Z, Shao S Front Med (Lausanne). 2025; 11():1491489.

PMID: 39776843 PMC: 11703827. DOI: 10.3389/fmed.2024.1491489.

Pulmonary Mucormycosis in an Older Acute Myeloid Leukemia Patient.

Luo B, Tan X, Chen Y, Chen L J Med Cases. 2025; 16(1):23-27.

PMID: 39759161 PMC: 11699860. DOI: 10.14740/jmc5042.

References

Vehreschild J, Birtel A, Vehreschild M, Liss B, Farowski F, Kochanek M . Mucormycosis treated with posaconazole: review of 96 case reports. Crit Rev Microbiol. 2012; 39(3):310-24. DOI: 10.3109/1040841X.2012.711741. View

Lanternier F, Sun H, Ribaud P, Singh N, Kontoyiannis D, Lortholary O . Mucormycosis in organ and stem cell transplant recipients. Clin Infect Dis. 2012; 54(11):1629-36. DOI: 10.1093/cid/cis195. View

Ribes J, Baker D . Zygomycetes in human disease. Clin Microbiol Rev. 2001; 13(2):236-301. PMC: 100153. DOI: 10.1128/CMR.13.2.236. View

Siddiqi S, Freedman J . Isolated central nervous system mucormycosis. South Med J. 1994; 87(10):997-1000. DOI: 10.1097/00007611-199410000-00006. View

Dolton M, Ray J, Chen S, Ng K, Pont L, McLachlan A . Multicenter study of posaconazole therapeutic drug monitoring: exposure-response relationship and factors affecting concentration. Antimicrob Agents Chemother. 2012; 56(11):5503-10. PMC: 3486529. DOI: 10.1128/AAC.00802-12. View

Lanternier F, Poiree S, Elie C, Garcia-Hermoso D, Bakouboula P, Sitbon K . Prospective pilot study of high-dose (10 mg/kg/day) liposomal amphotericin B (L-AMB) for the initial treatment of mucormycosis. J Antimicrob Chemother. 2015; 70(11):3116-23. DOI: 10.1093/jac/dkv236. View

Ostrosky-Zeichner L, Alexander B, Kett D, Vazquez J, Pappas P, Saeki F . Multicenter clinical evaluation of the (1-->3) beta-D-glucan assay as an aid to diagnosis of fungal infections in humans. Clin Infect Dis. 2005; 41(5):654-9. DOI: 10.1086/432470. View

Kontoyiannis D, Wessel V, Bodey G, Rolston K . Zygomycosis in the 1990s in a tertiary-care cancer center. Clin Infect Dis. 2000; 30(6):851-6. DOI: 10.1086/313803. View

Skiada A, Pagano L, Groll A, Zimmerli S, DuPont B, Lagrou K . Zygomycosis in Europe: analysis of 230 cases accrued by the registry of the European Confederation of Medical Mycology (ECMM) Working Group on Zygomycosis between 2005 and 2007. Clin Microbiol Infect. 2011; 17(12):1859-67. DOI: 10.1111/j.1469-0691.2010.03456.x. View

10.

Warkentien T, Rodriguez C, Lloyd B, Wells J, Weintrob A, Dunne J . Invasive mold infections following combat-related injuries. Clin Infect Dis. 2012; 55(11):1441-9. PMC: 3657499. DOI: 10.1093/cid/cis749. View

11.

Walther G, Wagner L, Kurzai O . Updates on the Taxonomy of Mucorales with an Emphasis on Clinically Important Taxa. J Fungi (Basel). 2019; 5(4). PMC: 6958464. DOI: 10.3390/jof5040106. View

12.

Park B, Pappas P, Wannemuehler K, Alexander B, Anaissie E, Andes D . Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006. Emerg Infect Dis. 2011; 17(10):1855-64. PMC: 3311117. DOI: 10.3201/eid1710.110087. View

13.

Lionakis M, Kontoyiannis D . Glucocorticoids and invasive fungal infections. Lancet. 2003; 362(9398):1828-38. DOI: 10.1016/S0140-6736(03)14904-5. View

14.

Fanfair R, Benedict K, Bos J, Bennett S, Lo Y, Adebanjo T . Necrotizing cutaneous mucormycosis after a tornado in Joplin, Missouri, in 2011. N Engl J Med. 2012; 367(23):2214-25. DOI: 10.1056/NEJMoa1204781. View

15.

Krishna G, Ma L, Martinho M, Preston R, OMara E . A new solid oral tablet formulation of posaconazole: a randomized clinical trial to investigate rising single- and multiple-dose pharmacokinetics and safety in healthy volunteers. J Antimicrob Chemother. 2012; 67(11):2725-30. PMC: 3468079. DOI: 10.1093/jac/dks268. View

16.

Petrikkos G, Tsioutis C . Recent Advances in the Pathogenesis of Mucormycoses. Clin Ther. 2018; 40(6):894-902. DOI: 10.1016/j.clinthera.2018.03.009. View

17.

Forrest G, Mankes K . Outcomes of invasive zygomycosis infections in renal transplant recipients. Transpl Infect Dis. 2007; 9(2):161-4. DOI: 10.1111/j.1399-3062.2006.00197.x. View

18.

Pettit N, Miceli M, Rivera C, Narayanan P, Perissinotti A, Hsu M . Multicentre study of posaconazole delayed-release tablet serum level and association with hepatotoxicity and QTc prolongation. J Antimicrob Chemother. 2017; 72(8):2355-2358. PMC: 5890703. DOI: 10.1093/jac/dkx122. View

19.

Weng D, Wilson W, Little R, Walsh T . Successful medical management of isolated renal zygomycosis: case report and review. Clin Infect Dis. 1998; 26(3):601-5. DOI: 10.1086/514562. View

20.

Ma B, Seymour J, Januszewicz H, Slavin M . Cure of pulmonary Rhizomucor pusillus infection in a patient with hairy-cell leukemia: role of liposomal amphotericin B and GM-CSF. Leuk Lymphoma. 2002; 42(6):1393-9. DOI: 10.3109/10428190109097768. View